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Association of white blood cell count with metabolic syndrome in patients undergoing peritoneal dialysis

Authors
 Jung Tak Park  ;  Tae Ik Chang  ;  Dong Ki Kim  ;  Hoon Young Choi  ;  Jung Eun Lee  ;  Hyun Wook Kim  ;  Jae Hyun Chang  ;  Sun Young Park  ;  Eunyoung Kim  ;  Tae-Hyun Yoo  ;  Dae-Suk Han  ;  Shin-Wook Kang 
Citation
 METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.58(10) : 1379-1385, 2009 
Journal Title
 METABOLISM-CLINICAL AND EXPERIMENTAL 
ISSN
 0026-0495 
Issue Date
2009
MeSH
Adult ; Blood Glucose/metabolism ; Body Mass Index ; Cross-Sectional Studies ; Dialysis Solutions/metabolism ; Female ; Glucose/metabolism ; Humans ; Insulin/blood ; Insulin Resistance ; Kidney Failure, Chronic/blood* ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Leukocyte Count* ; Leukocytes/physiology* ; Male ; Metabolic Syndrome/blood* ; Metabolic Syndrome/complications ; Peritoneal Dialysis* ; ROC Curve
Abstract
Metabolic syndrome is associated with an increased risk of diabetes and cardiovascular disease. Although some data suggest that the prevalence of metabolic syndrome is higher in patients undergoing peritoneal dialysis (PD), the factors related to this increased risk are not well elucidated. We therefore examined whether peripheral white blood cell (WBC) count is correlated with the risk of metabolic syndrome in nondiabetic PD patients. We enrolled 104 nondiabetic PD patients without current infections or chronic inflammatory diseases. Complete blood cell count, anthropometry, blood pressure, fasting glucose, insulin, and lipid profiles were measured. Metabolic syndrome was defined in accordance with the National Cholesterol Education Program (Adult Treatment Panel III) criteria. Metabolic syndrome was present in 49 patients (47.1%). Patients with metabolic syndrome had a higher WBC count and high-sensitivity C-reactive protein level. As the number of metabolic syndrome components increased, WBC count increased significantly. White blood cell count was significantly positively correlated with body mass index, insulin, homeostasis model assessment of insulin resistance, and triglyceride and negatively correlated with high-density lipoprotein cholesterol. The risk of metabolic syndrome increased significantly with a higher WBC count, resulting in an adjusted odds ratio of 1.65 (per 10(3)/muL increase, P = .002). These findings demonstrate that metabolic syndrome is prevalent among nondiabetic PD patients and that WBC count is strongly associated with metabolic syndrome and its components
Full Text
http://www.sciencedirect.com/science/article/pii/S0026049509001644
DOI
10.1016/j.metabol.2009.05.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Chang, Tae Ik(장태익)
Choi, Hoon Young(최훈영) ORCID logo https://orcid.org/0000-0002-4245-0339
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104668
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