무증상 성인에서 관상동맥 칼슘 수치와 공복 혈당의 연관성

Abstract

Background: Coronary artery calcium (CAC) is closely related with atherosclerosis and other vascular disease. The early identification of atherosclerosis in asymptomatic patients with pre-diabetes or diabetes could be possible by computed tomography (CT). We intend to figure out what is the most independently associated factor with coronary artery calcium score (CACS) in asymptomatic subjects.

Methods: In this cross-sectional study, a total of 751 people, with an age bracket of 18 to 70 years were recruited. Anthropometric measurement, medical history and lifestyle information, such as smoking and alcohol ingestion habits were taken. Fasting plasma glucose, lipid profile, high sensitivity C-reactive protein (hs-CRP), CACS were measured, non-HDL cholesterol was calculated. We assessed the correlation analysis and multiple linear regression analysis, which divided by three groups; CACS=0, 0＜CACS＜100, CACS≥100.

Results: CAC was positive associated with fasting plasma glucose. Other risk factors were correlated in one-way analysis, but only fasting glucose is independently associated, after adjustment for age,sex, BMI, blood pressure, hs-CRP, HDL-cholesterol, non-HDL cholesterol, smoking, alcohol and exercise. Glucose value of each group had a distinct difference; CAC=0; 93.4±8.2 mg/dl, 0＜CAC＜100; 97.2±8.8 mg/dl (P＜0.05), CAC≥100; 106±6.5 mg/dl (P＜0.001).

Conslusion: Fasting plasma glucose was the best independent factor of CAC among known cardiovascular disease risk factors.