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최근 임상검체에서의 혐기성 세균 분리 현황 및 혐기성 균혈증의 임상적 특징

Other Titles
 Recent Trends of Anaerobic Bacteria Isolated from Clinical Specimens and Clinical Characteristics of Anaerobic Bacteremia 
 박용정  ;  이양순  ;  김명숙  ;  최준용  ;  용동은  ;  정석훈  ;  김준명  ;  이경원  ;  정윤섭 
 INFECTION AND CHEMOTHERAPY (감염과 화학요법), Vol.41(4) : 216-223, 2009 
Journal Title
Issue Date
Anaerobe ; Bacteremia ; Bacteroides fragilis ; Clostridium perfringens
BACKGROUND: Anaerobic bacteria can cause various infections, and their incidence may differ greatly, depending on the country or hospital. We investigated recent trends in anaerobe isolation and clinical characteristics of anaerobic bacteremia in one hospital in Korea to facilitate diagnosis and treatment of anaerobic infections. MATERIALS AND METHODS: Anaerobic bacteria isolated from blood, body fluids and abscess specimens at a university hospital in Korea during 2007 and 2008 were analyzed. The medical records of 82 anaerobic bacteremia patients were reviewed. A retrospective cohort study was conducted to determine the risk factors for in-hospital mortality of patients with anaerobic bacteremia. RESULTS: A total of 289 non-duplicated anaerobic isolates were recovered from blood, body fluids and abscess specimens. Bacteroides fragilis (73 isolates, 25.3%) was the most common organism followed by Clostridium perfringens (22 isolates, 7.6%), Peptoniphilus asaccharolyticus (21 isolates, 7.3%) and Anaerococcus prevotii (19 isolates, 6.6%). Eighty-four isolates were recovered from blood specimens, among which B. fragilis (24 isolates) and C. perfringens (21 isolates) were the most frequently isolated organisms. Among the 196 underlying diseases of anaerobic bacteremia patients, neoplastic, infectious, and gastrointestinal diseases accounted for 54 (27.6%), 46 (23.5%), and 41 (20.9%) cases, respectively. The alimentary tract was the most common suspected portal of entry. The in-hospital mortality rate of anaerobic bacteremia patients was 34.2%, and neutropenia at the time of blood culture was the only statistically significant factor associated with mortality in this study. Anaerobes were isolated in 1.4% of all positive blood cultures. CONCLUSIONS: B. fragilis and C. perfringens are expected to be commonly isolated from clinical specimens. Despite its low prevalence, anaerobic bacteremia displays a significant in-hospital mortality rate. Ongoing investigations into anaerobic bacteremia are necessary because of ambiguous risk factors for mortality
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, June Myung(김준명)
Park, Yong Jung(박용정) ORCID logo https://orcid.org/0000-0001-5668-4120
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Lee, Yang Soon(이양순)
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
Chong, Yun Sop(정윤섭)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
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