Factors associated with HIV-1 proviral DNA loads in patients with undetectable plasma RNA load
Authors
Jun Yong Choi ; Young Goo Song ; Young Hwa Kim ; Chang Oh Kim ; Myung Soo Kim ; Bum Sik Chin ; Sang Hoon Han ; Suk Hoon Choi ; Han Sung Lee ; Su Jin Jeong ; Heekyoung Choi ; June Myung Kim
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.24(1) : 152-154, 2009
Anti-HIV Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; CD4-Positive T-Lymphocytes/virology ; Cross-Sectional Studies ; DNA, Viral/analysis* ; Female ; HIV Infections/drug therapy ; HIV-1/genetics* ; Humans ; Male ; Polymerase Chain Reaction ; Proviruses/genetics* ; RNA, Viral/blood
Keywords
HIV ; HIV Infections ; Acquired Immunodeficiency Syndrome ; Proviruses
Abstract
To evaluate factors associated with human immunodeficiency virus type 1 (HIV-1) proviral DNA load, we conducted a cross-sectional study of 36 chronically HIV-1- infected individuals with undetectable plasma viral RNA. We used real-time polymerase chain reaction to determine the number of HIV-1 proviral DNA copies per 10(6) peripheral blood mononuclear cells. The mean level of plasma viral RNA when the CD4+ T cell count was above 500 cells/microliter without highly active antiretroviral therapy (HAART) was significantly associated with proviral DNA load at the time of undetectable plasma HIV RNA with HAART. Strategies to reduce the level of plasma viral RNA when patients' CD4+ T cell counts are above 500 cells/microliter without HAART could help reduce HIV-1 proviral DNA load