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Factors associated with HIV-1 proviral DNA loads in patients with undetectable plasma RNA load

Authors
 Jun Yong Choi  ;  Young Goo Song  ;  Young Hwa Kim  ;  Chang Oh Kim  ;  Myung Soo Kim  ;  Bum Sik Chin  ;  Sang Hoon Han  ;  Suk Hoon Choi  ;  Han Sung Lee  ;  Su Jin Jeong  ;  Heekyoung Choi  ;  June Myung Kim 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.24(1) : 152-154, 2009 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2009
MeSH
Anti-HIV Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; CD4-Positive T-Lymphocytes/virology ; Cross-Sectional Studies ; DNA, Viral/analysis* ; Female ; HIV Infections/drug therapy ; HIV-1/genetics* ; Humans ; Male ; Polymerase Chain Reaction ; Proviruses/genetics* ; RNA, Viral/blood
Keywords
HIV ; HIV Infections ; Acquired Immunodeficiency Syndrome ; Proviruses
Abstract
To evaluate factors associated with human immunodeficiency virus type 1 (HIV-1) proviral DNA load, we conducted a cross-sectional study of 36 chronically HIV-1- infected individuals with undetectable plasma viral RNA. We used real-time polymerase chain reaction to determine the number of HIV-1 proviral DNA copies per 10(6) peripheral blood mononuclear cells. The mean level of plasma viral RNA when the CD4+ T cell count was above 500 cells/microliter without highly active antiretroviral therapy (HAART) was significantly associated with proviral DNA load at the time of undetectable plasma HIV RNA with HAART. Strategies to reduce the level of plasma viral RNA when patients' CD4+ T cell counts are above 500 cells/microliter without HAART could help reduce HIV-1 proviral DNA load
Files in This Item:
T200902812.pdf Download
DOI
10.3346/jkms.2009.24.1.152
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Lee, Han Sung(이한성)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Chin, Bum Sik(진범식)
Choi, Suk Hoon(최석훈)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Hee Kyoung(최희경)
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104402
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