3 230

Cited 0 times in

Human anti-alpha-enolase antibody in sera from patients with Behçet's disease and rheumatologic disorders

Authors
 J.H. Lee  ;  S.B. Cho  ;  D. Bang  ;  S.H. Oh  ;  K.-J. Ahn  ;  J. Kim  ;  Y.-B. Park  ;  S.-K. Lee  ;  K.H. Lee 
Citation
 Clinical and Experimental Rheumatology, Vol.27(2 suppl 53) : 63-66, 2009 
Journal Title
 Clinical and Experimental Rheumatology 
ISSN
 0392-856X 
Issue Date
2009
Abstract
OBJECTIVE: alpha-Enolase is a target antigen of IgM-type anti-endothelial cell antibody in patients with Behçet's disease (BD). The objective of this study was to assess the reactivity of serum anti-alpha-enolase antibodies in BD and in other rheumatologic diseases, and to evaluate the clinical significance of serum anti-alpha-enolase antibodies in BD. METHODS: Enzyme-linked immunosorbent assay (ELISA) and immunoblotting were used to examine serum samples from patients with BD (n=100), systemic lupus erythematosus (SLE) (n=50), systemic sclerosis (n=21), rheumatoid arthritis (RA) (n=20), Takayasu's arteritis (n=20), dermatomyositis (n=17), mixed connective tissue disease (MCTD) (n=11), and samples from healthy volunteer donors (n=23). The medical records of patients with BD were reviewed to investigate their clinical characteristics. RESULTS: Specific positive signals against recombinant human alpha-enolase were detected by IgM ELISA of serum samples from 56 of the 100 BD patients (56.0%), 24 of the 50 SLE patients (48.0%), 15 of the 21 systemic sclerosis patients (71.4%), 13 of the 20 RA patients (65.0%), 10 of the 20 Takayasu's arteritis patients (50.0%), 9 of the 17 dermatomyositis patients (52.9%), and 5 of the 11 MCTD patients (45.5%). The number of BD patients with vascular lesions was significantly higher in the anti-alpha-enolase antibody positive group than in the negative group (p=0.027). CONCLUSION: We demonstrated the reactivities of serum anti-alpha-enolase antibodies in BD and other rheumatologic diseases with moderate specificity and also found that serum anti-alpha-enolase antibodies in BD can be associated with vascular system involvement
Full Text
http://www.clinexprheumatol.org/pubmed/find-pii.asp?pii=19796536
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
박용범(Park, Yong Beom)
방동식(Bang, Dong Sik)
안근재(Ahn, Keun Jae)
오상호(Oh, Sang Ho) ORCID logo https://orcid.org/0000-0002-4477-1400
이광훈(Lee, Kwang Hoon)
이수곤(Lee, Soo Kon)
이주희(Lee, Ju Hee) ORCID logo https://orcid.org/0000-0002-1739-5956
조성빈(Cho, Sung Bin)
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104370
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse