3 318

Cited 0 times in

Human anti-alpha-enolase antibody in sera from patients with Behçet's disease and rheumatologic disorders

DC FieldValueLanguage
dc.contributor.author이수곤-
dc.contributor.author이주희-
dc.contributor.author조성빈-
dc.contributor.author박용범-
dc.contributor.author방동식-
dc.contributor.author안근재-
dc.contributor.author오상호-
dc.contributor.author이광훈-
dc.date.accessioned2015-04-24T16:53:33Z-
dc.date.available2015-04-24T16:53:33Z-
dc.date.issued2009-
dc.identifier.issn0392-856X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104370-
dc.description.abstractOBJECTIVE: alpha-Enolase is a target antigen of IgM-type anti-endothelial cell antibody in patients with Behçet's disease (BD). The objective of this study was to assess the reactivity of serum anti-alpha-enolase antibodies in BD and in other rheumatologic diseases, and to evaluate the clinical significance of serum anti-alpha-enolase antibodies in BD. METHODS: Enzyme-linked immunosorbent assay (ELISA) and immunoblotting were used to examine serum samples from patients with BD (n=100), systemic lupus erythematosus (SLE) (n=50), systemic sclerosis (n=21), rheumatoid arthritis (RA) (n=20), Takayasu's arteritis (n=20), dermatomyositis (n=17), mixed connective tissue disease (MCTD) (n=11), and samples from healthy volunteer donors (n=23). The medical records of patients with BD were reviewed to investigate their clinical characteristics. RESULTS: Specific positive signals against recombinant human alpha-enolase were detected by IgM ELISA of serum samples from 56 of the 100 BD patients (56.0%), 24 of the 50 SLE patients (48.0%), 15 of the 21 systemic sclerosis patients (71.4%), 13 of the 20 RA patients (65.0%), 10 of the 20 Takayasu's arteritis patients (50.0%), 9 of the 17 dermatomyositis patients (52.9%), and 5 of the 11 MCTD patients (45.5%). The number of BD patients with vascular lesions was significantly higher in the anti-alpha-enolase antibody positive group than in the negative group (p=0.027). CONCLUSION: We demonstrated the reactivities of serum anti-alpha-enolase antibodies in BD and other rheumatologic diseases with moderate specificity and also found that serum anti-alpha-enolase antibodies in BD can be associated with vascular system involvement-
dc.description.statementOfResponsibilityopen-
dc.format.extents63~s66-
dc.relation.isPartOfCLINICAL AND EXPERIMENTAL RHEUMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAutoantibodies/blood*-
dc.subject.MESHBehcet Syndrome/complications-
dc.subject.MESHBehcet Syndrome/enzymology*-
dc.subject.MESHBehcet Syndrome/immunology-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin M/blood*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPhosphopyruvate Hydratase/immunology*-
dc.subject.MESHRheumatic Diseases/enzymology*-
dc.subject.MESHRheumatic Diseases/immunology-
dc.subject.MESHVasculitis/complications-
dc.subject.MESHVasculitis/enzymology-
dc.subject.MESHVasculitis/immunology-
dc.titleHuman anti-alpha-enolase antibody in sera from patients with Behçet's disease and rheumatologic disorders-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorJ.H. Lee-
dc.contributor.googleauthorS.B. Cho-
dc.contributor.googleauthorD. Bang-
dc.contributor.googleauthorS.H. Oh-
dc.contributor.googleauthorK.-J. Ahn-
dc.contributor.googleauthorJ. Kim-
dc.contributor.googleauthorY.-B. Park-
dc.contributor.googleauthorS.-K. Lee-
dc.contributor.googleauthorK.H. Lee-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02889-
dc.contributor.localIdA03832-
dc.contributor.localIdA01579-
dc.contributor.localIdA01784-
dc.contributor.localIdA02222-
dc.contributor.localIdA02370-
dc.contributor.localIdA03171-
dc.contributor.localIdA02674-
dc.relation.journalcodeJ00555-
dc.identifier.eissn1593-098X-
dc.identifier.pmid19796536-
dc.identifier.urlhttp://www.clinexprheumatol.org/pubmed/find-pii.asp?pii=19796536-
dc.subject.keywordBehçet’s disease-
dc.subject.keywordenolase-
dc.subject.keywordsystemic lupus erythematosus-
dc.subject.keyworddermatomyositis-
dc.subject.keywordrheumatoid arthritis-
dc.subject.keywordTakayasu’s arteritis-
dc.contributor.alternativeNameLee, Soo Kon-
dc.contributor.alternativeNameLee, Ju Hee-
dc.contributor.alternativeNameCho, Sung Bin-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.alternativeNameBang, Dong Sik-
dc.contributor.alternativeNameAhn, Keun Jae-
dc.contributor.alternativeNameOh, Sang Ho-
dc.contributor.alternativeNameLee, Kwang Hoon-
dc.contributor.affiliatedAuthorLee, Soo Kon-
dc.contributor.affiliatedAuthorCho, Sung Bin-
dc.contributor.affiliatedAuthorPark, Yong Beom-
dc.contributor.affiliatedAuthorBang, Dong Sik-
dc.contributor.affiliatedAuthorAhn, Keun Jae-
dc.contributor.affiliatedAuthorOh, Sang Ho-
dc.contributor.affiliatedAuthorLee, Ju Hee-
dc.contributor.affiliatedAuthorLee, Kwang Hoon-
dc.citation.volume27-
dc.citation.number2 suppl 53-
dc.citation.startPage63-
dc.citation.endPage66-
dc.identifier.bibliographicCitationCLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol.27(2 suppl 53) : 63-66, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.