Cited 0 times in
Human anti-alpha-enolase antibody in sera from patients with Behçet's disease and rheumatologic disorders
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수곤 | - |
dc.contributor.author | 이주희 | - |
dc.contributor.author | 조성빈 | - |
dc.contributor.author | 박용범 | - |
dc.contributor.author | 방동식 | - |
dc.contributor.author | 안근재 | - |
dc.contributor.author | 오상호 | - |
dc.contributor.author | 이광훈 | - |
dc.date.accessioned | 2015-04-24T16:53:33Z | - |
dc.date.available | 2015-04-24T16:53:33Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0392-856X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104370 | - |
dc.description.abstract | OBJECTIVE: alpha-Enolase is a target antigen of IgM-type anti-endothelial cell antibody in patients with Behçet's disease (BD). The objective of this study was to assess the reactivity of serum anti-alpha-enolase antibodies in BD and in other rheumatologic diseases, and to evaluate the clinical significance of serum anti-alpha-enolase antibodies in BD. METHODS: Enzyme-linked immunosorbent assay (ELISA) and immunoblotting were used to examine serum samples from patients with BD (n=100), systemic lupus erythematosus (SLE) (n=50), systemic sclerosis (n=21), rheumatoid arthritis (RA) (n=20), Takayasu's arteritis (n=20), dermatomyositis (n=17), mixed connective tissue disease (MCTD) (n=11), and samples from healthy volunteer donors (n=23). The medical records of patients with BD were reviewed to investigate their clinical characteristics. RESULTS: Specific positive signals against recombinant human alpha-enolase were detected by IgM ELISA of serum samples from 56 of the 100 BD patients (56.0%), 24 of the 50 SLE patients (48.0%), 15 of the 21 systemic sclerosis patients (71.4%), 13 of the 20 RA patients (65.0%), 10 of the 20 Takayasu's arteritis patients (50.0%), 9 of the 17 dermatomyositis patients (52.9%), and 5 of the 11 MCTD patients (45.5%). The number of BD patients with vascular lesions was significantly higher in the anti-alpha-enolase antibody positive group than in the negative group (p=0.027). CONCLUSION: We demonstrated the reactivities of serum anti-alpha-enolase antibodies in BD and other rheumatologic diseases with moderate specificity and also found that serum anti-alpha-enolase antibodies in BD can be associated with vascular system involvement | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | s63~s66 | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Autoantibodies/blood* | - |
dc.subject.MESH | Behcet Syndrome/complications | - |
dc.subject.MESH | Behcet Syndrome/enzymology* | - |
dc.subject.MESH | Behcet Syndrome/immunology | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin M/blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Phosphopyruvate Hydratase/immunology* | - |
dc.subject.MESH | Rheumatic Diseases/enzymology* | - |
dc.subject.MESH | Rheumatic Diseases/immunology | - |
dc.subject.MESH | Vasculitis/complications | - |
dc.subject.MESH | Vasculitis/enzymology | - |
dc.subject.MESH | Vasculitis/immunology | - |
dc.title | Human anti-alpha-enolase antibody in sera from patients with Behçet's disease and rheumatologic disorders | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | J.H. Lee | - |
dc.contributor.googleauthor | S.B. Cho | - |
dc.contributor.googleauthor | D. Bang | - |
dc.contributor.googleauthor | S.H. Oh | - |
dc.contributor.googleauthor | K.-J. Ahn | - |
dc.contributor.googleauthor | J. Kim | - |
dc.contributor.googleauthor | Y.-B. Park | - |
dc.contributor.googleauthor | S.-K. Lee | - |
dc.contributor.googleauthor | K.H. Lee | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02889 | - |
dc.contributor.localId | A03832 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A01784 | - |
dc.contributor.localId | A02222 | - |
dc.contributor.localId | A02370 | - |
dc.contributor.localId | A03171 | - |
dc.contributor.localId | A02674 | - |
dc.relation.journalcode | J00555 | - |
dc.identifier.eissn | 1593-098X | - |
dc.identifier.pmid | 19796536 | - |
dc.identifier.url | http://www.clinexprheumatol.org/pubmed/find-pii.asp?pii=19796536 | - |
dc.subject.keyword | Behçet’s disease | - |
dc.subject.keyword | enolase | - |
dc.subject.keyword | systemic lupus erythematosus | - |
dc.subject.keyword | dermatomyositis | - |
dc.subject.keyword | rheumatoid arthritis | - |
dc.subject.keyword | Takayasu’s arteritis | - |
dc.contributor.alternativeName | Lee, Soo Kon | - |
dc.contributor.alternativeName | Lee, Ju Hee | - |
dc.contributor.alternativeName | Cho, Sung Bin | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Bang, Dong Sik | - |
dc.contributor.alternativeName | Ahn, Keun Jae | - |
dc.contributor.alternativeName | Oh, Sang Ho | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Soo Kon | - |
dc.contributor.affiliatedAuthor | Cho, Sung Bin | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Bang, Dong Sik | - |
dc.contributor.affiliatedAuthor | Ahn, Keun Jae | - |
dc.contributor.affiliatedAuthor | Oh, Sang Ho | - |
dc.contributor.affiliatedAuthor | Lee, Ju Hee | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Hoon | - |
dc.citation.volume | 27 | - |
dc.citation.number | 2 suppl 53 | - |
dc.citation.startPage | 63 | - |
dc.citation.endPage | 66 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol.27(2 suppl 53) : 63-66, 2009 | - |
dc.identifier.rimsid | 52624 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.