0 371

Cited 21 times in

BiomarkerDigger: a versatile disease proteome database and analysis platform for the identification of plasma cancer biomarkers

Authors
 Seul-Ki Jeong  ;  Min-Seok Kwon  ;  Eun-Young Lee  ;  Hyoung-Joo Lee  ;  Sang Yun Cho  ;  Hoguen Kim  ;  Jong Shin Yoo  ;  Gilbert S. Omenn  ;  Ruedi Aebersold  ;  Sam Hanash  ;  Young-Ki Paik 
Citation
 PROTEOMICS, Vol.9(14) : 3729-3740, 2009 
Journal Title
PROTEOMICS
ISSN
 1615-9853 
Issue Date
2009
MeSH
Biomarkers, Tumor/analysis* ; Computational Biology/methods ; Databases, Protein* ; Humans ; Models, Theoretical ; Neoplasms, Plasma Cell/metabolism* ; Proteomics/methods* ; Software* ; User-Computer Interface
Keywords
BiomarkerDigger ; Database ; HUPO ; Plasma proteome
Abstract
We have developed a proteome database (DB), BiomarkerDigger (http://biomarkerdigger.org) that automates data analysis, searching, and metadata-gathering function. the metadata-gathering function searches proteome DBs for protein-protein interaction, Gene Ontology, protein domain, Online Mendelian Inheritance in Man, and tissue expression profile information and integrates it into protein data sets that are accessed through a search function in BiomarkerDigger. This DB also facilitates cross-proteome comparisons by classifying proteins based on their annotation. BiomarkerDigger highlights relationships between a given protein in a proteomic data set and any known biomarkers or biomarker candidates. the newly developed BiomarkerDigger system is useful for multi-level synthesis, comparison, and analyses of data sets obtained from currently available web sources. We demonstrate the application of this resource to the identification of a serological biomarker for hepatocellular carcinoma by comparison of plasma and tissue proteomic data sets from healthy volunteers and cancer patients.
Full Text
http://dx.doi.org/10.1002/pmic.200800593
DOI
10.1002/pmic.200800593
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hogeun(김호근)
Jeong, Seul Ki(정슬기)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104367
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links