Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics.

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Authors: Juwon Kim ; Tae Sung Park ; Jaewoo Song ; Lee Kyung-A ; Duk Jin Hong ; Yoo Hong Min ; June-Won Cheong ; Jong Rak Choi

MeSH: Adult ; Aged ; Base Sequence ; Chromosomes, Human, Pair 16* ; Chromosomes, Human, Pair 21* ; Cytogenetic Analysis ; DNA Mutational Analysis ; Female ; Humans ; Leukemia, Myeloid, Acute/genetics* ; Leukemia, Myeloid, Acute/pathology ; Male ; Oncogene Proteins, Fusion/genetics* ; Oncogene Proteins, Fusion/isolation & purification ; RNA, Messenger/genetics ; RNA, Messenger/isolation & purification ; RNA-Binding Protein FUS/genetics* ; RNA-Binding Protein FUS/isolation & purification ; Translocation, Genetic*

Abstract: Reciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS-ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t(16;21), along with a review of the literature.

Full Text: http://www.sciencedirect.com/science/article/pii/S0165460809003276

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

Yonsei Authors: Min, Yoo Hong(민유홍) https://orcid.org/0000-0001-8542-9583
Park, Tae Sung(박태성)
Song, Jae Woo(송재우) https://orcid.org/0000-0002-1877-5731
Lee, Kyung A(이경아) https://orcid.org/0000-0001-5320-6705
Cheong, June-Won(정준원) https://orcid.org/0000-0002-1744-0921
Choi, Jong Rak(최종락) https://orcid.org/0000-0002-0608-2989

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YUHSpace: Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics.