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Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics.

DC Field Value Language
dc.contributor.author민유홍-
dc.contributor.author박태성-
dc.contributor.author송재우-
dc.contributor.author이경아-
dc.contributor.author정준원-
dc.contributor.author최종락-
dc.date.accessioned2015-04-24T16:53:16Z-
dc.date.available2015-04-24T16:53:16Z-
dc.date.issued2009-
dc.identifier.issn0165-4608-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104361-
dc.description.abstractReciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS-ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t(16;21), along with a review of the literature.-
dc.description.statementOfResponsibilityopen-
dc.format.extent111~118-
dc.relation.isPartOfCANCER GENETICS AND CYTOGENETICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBase Sequence-
dc.subject.MESHChromosomes, Human, Pair 16*-
dc.subject.MESHChromosomes, Human, Pair 21*-
dc.subject.MESHCytogenetic Analysis-
dc.subject.MESHDNA Mutational Analysis-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLeukemia, Myeloid, Acute/genetics*-
dc.subject.MESHLeukemia, Myeloid, Acute/pathology-
dc.subject.MESHMale-
dc.subject.MESHOncogene Proteins, Fusion/genetics*-
dc.subject.MESHOncogene Proteins, Fusion/isolation & purification-
dc.subject.MESHRNA, Messenger/genetics-
dc.subject.MESHRNA, Messenger/isolation & purification-
dc.subject.MESHRNA-Binding Protein FUS/genetics*-
dc.subject.MESHRNA-Binding Protein FUS/isolation & purification-
dc.subject.MESHTranslocation, Genetic*-
dc.titleDetection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorJuwon Kim-
dc.contributor.googleauthorTae Sung Park-
dc.contributor.googleauthorJaewoo Song-
dc.contributor.googleauthorLee Kyung-A-
dc.contributor.googleauthorDuk Jin Hong-
dc.contributor.googleauthorYoo Hong Min-
dc.contributor.googleauthorJune-Won Cheong-
dc.contributor.googleauthorJong Rak Choi-
dc.identifier.doi10.1016/j.cancergencyto.2009.06.010-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01407-
dc.contributor.localIdA01725-
dc.contributor.localIdA02054-
dc.contributor.localIdA02647-
dc.contributor.localIdA03729-
dc.contributor.localIdA04182-
dc.relation.journalcodeJ00443-
dc.identifier.eissn1873-4456-
dc.identifier.pmid1981443-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0165460809003276-
dc.contributor.alternativeNameMin, Yoo Hong-
dc.contributor.alternativeNamePark, Tae Sung-
dc.contributor.alternativeNameSong, Jae Woo-
dc.contributor.alternativeNameLee, Kyung A-
dc.contributor.alternativeNameCheong, June Won-
dc.contributor.alternativeNameChoi, Jong Rak-
dc.contributor.affiliatedAuthorMin, Yoo Hong-
dc.contributor.affiliatedAuthorPark, Tae Sung-
dc.contributor.affiliatedAuthorSong, Jae Woo-
dc.contributor.affiliatedAuthorLee, Kyung A-
dc.contributor.affiliatedAuthorCheong, June-Won-
dc.contributor.affiliatedAuthorChoi, Jong Rak-
dc.citation.volume194-
dc.citation.number2-
dc.citation.startPage111-
dc.citation.endPage118-
dc.identifier.bibliographicCitationCANCER GENETICS AND CYTOGENETICS , Vol.194(2) : 111-118, 2009-
dc.identifier.rimsid52618-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
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