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Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics.

Authors
 Juwon Kim  ;  Tae Sung Park  ;  Jaewoo Song  ;  Lee Kyung-A  ;  Duk Jin Hong  ;  Yoo Hong Min  ;  June-Won Cheong  ;  Jong Rak Choi 
Citation
 CANCER GENETICS AND CYTOGENETICS , Vol.194(2) : 111-118, 2009 
Journal Title
 CANCER GENETICS AND CYTOGENETICS 
ISSN
 0165-4608 
Issue Date
2009
MeSH
Adult ; Aged ; Base Sequence ; Chromosomes, Human, Pair 16* ; Chromosomes, Human, Pair 21* ; Cytogenetic Analysis ; DNA Mutational Analysis ; Female ; Humans ; Leukemia, Myeloid, Acute/genetics* ; Leukemia, Myeloid, Acute/pathology ; Male ; Oncogene Proteins, Fusion/genetics* ; Oncogene Proteins, Fusion/isolation & purification ; RNA, Messenger/genetics ; RNA, Messenger/isolation & purification ; RNA-Binding Protein FUS/genetics* ; RNA-Binding Protein FUS/isolation & purification ; Translocation, Genetic*
Abstract
Reciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS-ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t(16;21), along with a review of the literature.
Full Text
http://www.sciencedirect.com/science/article/pii/S0165460809003276
DOI
10.1016/j.cancergencyto.2009.06.010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Min, Yoo Hong(민유홍) ORCID logo https://orcid.org/0000-0001-8542-9583
Park, Tae Sung(박태성)
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104361
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