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Xenografted Tumorigenesis in the oral vestibule of nude mice by Snail transfection: Histological and immunohistochemical study

Other Titles
 Snail transfection을 이용한 누드마우스에서의 침윤성 종양 형성 
Authors
 Moon-Key Kim  ;  Eun-Ha Lee  ;  Jin Kim  ;  Jong-In Yook  ;  In-Ho Cha 
Citation
 Journal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지), Vol.35(4) : 199-204, 2009 
Journal Title
 Journal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지) 
ISSN
 1225-1585 
Issue Date
2009
Keywords
E-cadherin ; neoplastic cell transformation ; Snail transcription factor ; xenograft model
Abstract
Purpose: The purpose of this study is to investigate the epithelial-mesenchymal transition (EMT) induced by Snail transcription factor and Snailtransfected in vivo tumors with histopathological features. Materials and methods: We induced in vivo xenografted tumorigenesis in the oral vestibules of nude mice by a Snail transfected HaCaT cell line and investigated morphological and immunohistochemical features in Snail expressive tumors. Results: We identified tumor masses in 14 out of 15 nude mice in the HaCaT-Snail cell inoculation group, but no tumors were present in any of the HaCaT cell inoculation group. Induced tumors showed features of poorly differentiated carcinoma with invasion to neighboring muscles and bones. The HaCaT-Snail tumors showed decreased expressions of E-cadherin and cytokeratin, but showed increased expressions of vimentin and N-cadherin. Discussion: The Snail transfected xenograft can improve productivity of malignant tumors, show various histopathological features including invasive growth, and aid in the investigation of tumor progression and the interaction with surrounding tissues.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Moon Key(김문기)
Kim, Jin(김진)
Yook, Jong In(육종인) ORCID logo https://orcid.org/0000-0002-7318-6112
Lee, Eun Ha(이은하)
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104340
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