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Xenografted Tumorigenesis in the oral vestibule of nude mice by Snail transfection: Histological and immunohistochemical study

DC Field Value Language
dc.contributor.author김문기-
dc.contributor.author김진-
dc.contributor.author육종인-
dc.contributor.author이은하-
dc.contributor.author차인호-
dc.date.accessioned2015-04-24T16:52:35Z-
dc.date.available2015-04-24T16:52:35Z-
dc.date.issued2009-
dc.identifier.issn1225-1585-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104340-
dc.description.abstractPurpose: The purpose of this study is to investigate the epithelial-mesenchymal transition (EMT) induced by Snail transcription factor and Snailtransfected in vivo tumors with histopathological features. Materials and methods: We induced in vivo xenografted tumorigenesis in the oral vestibules of nude mice by a Snail transfected HaCaT cell line and investigated morphological and immunohistochemical features in Snail expressive tumors. Results: We identified tumor masses in 14 out of 15 nude mice in the HaCaT-Snail cell inoculation group, but no tumors were present in any of the HaCaT cell inoculation group. Induced tumors showed features of poorly differentiated carcinoma with invasion to neighboring muscles and bones. The HaCaT-Snail tumors showed decreased expressions of E-cadherin and cytokeratin, but showed increased expressions of vimentin and N-cadherin. Discussion: The Snail transfected xenograft can improve productivity of malignant tumors, show various histopathological features including invasive growth, and aid in the investigation of tumor progression and the interaction with surrounding tissues.-
dc.description.statementOfResponsibilityopen-
dc.format.extent199~204-
dc.relation.isPartOfJournal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleXenografted Tumorigenesis in the oral vestibule of nude mice by Snail transfection: Histological and immunohistochemical study-
dc.title.alternativeSnail transfection을 이용한 누드마우스에서의 침윤성 종양 형성-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Pathology (구강병리학)-
dc.contributor.googleauthorMoon-Key Kim-
dc.contributor.googleauthorEun-Ha Lee-
dc.contributor.googleauthorJin Kim-
dc.contributor.googleauthorJong-In Yook-
dc.contributor.googleauthorIn-Ho Cha-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00437-
dc.contributor.localIdA02536-
dc.contributor.localIdA03051-
dc.contributor.localIdA04002-
dc.contributor.localIdA01009-
dc.relation.journalcodeJ01806-
dc.subject.keywordE-cadherin-
dc.subject.keywordneoplastic cell transformation-
dc.subject.keywordSnail transcription factor-
dc.subject.keywordxenograft model-
dc.contributor.alternativeNameKim, Moon Key-
dc.contributor.alternativeNameKim, Jin-
dc.contributor.alternativeNameYook, Jong In-
dc.contributor.alternativeNameLee, Eun Ha-
dc.contributor.alternativeNameCha, In Ho-
dc.contributor.affiliatedAuthorKim, Moon Key-
dc.contributor.affiliatedAuthorYook, Jong In-
dc.contributor.affiliatedAuthorLee, Eun Ha-
dc.contributor.affiliatedAuthorCha, In Ho-
dc.contributor.affiliatedAuthorKim, Jin-
dc.citation.volume35-
dc.citation.number4-
dc.citation.startPage199-
dc.citation.endPage204-
dc.identifier.bibliographicCitationJournal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지), Vol.35(4) : 199-204, 2009-
dc.identifier.rimsid52606-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers

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