Cited 30 times in
Alteration of RANKL-induced osteoclastogenesis in primary cultured osteoclasts from SERCA2+/- mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경호 | - |
dc.contributor.author | 서정택 | - |
dc.contributor.author | 손승화 | - |
dc.contributor.author | 신동민 | - |
dc.contributor.author | 이승일 | - |
dc.contributor.author | 홍정희 | - |
dc.date.accessioned | 2015-04-24T16:51:49Z | - |
dc.date.available | 2015-04-24T16:51:49Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0884-0431 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104316 | - |
dc.description.abstract | RANKL is essential for the terminal differentiation of monocytes/macrophages into osteoclasts. RANKL induces long-lasting oscillations in the intracellular concentration of Ca(2+) ([Ca(2+)](i)) only after 24 h of stimulation. These Ca(2+) oscillations play a switch-on role in NFATc1 expression and osteoclast differentiation. Which Ca(2+) transporting pathway is induced by RANKL to evoke the Ca(2+) oscillations and its specific role in RANKL-mediated osteoclast differentiation is not known. This study examined the effect of a partial loss of sarco/endoplasmic reticulum Ca(2+) ATPase type 2 (SERCA2) on osteoclast differentiation in SERCA2 heterozygote mice (SERCA2(+/-)). The BMD in the tibias of SERCA2(+/-) mice increased >1.5-fold compared with wildtype mice (WT). RANKL-induced [Ca(2+)](i) oscillations were generated 48 h after RANKL treatment in the WT mice but not in the SERCA2(+/-) bone marrow-derived macrophages (BMMs). Forty-eight hours after RANKL treatment, there was a lower level of NFATc1 protein expression and markedly reduced translocation of NFATc1 into the nucleus during osteoclastogenesis of the SERCA2(+/-) BMMs. In addition, RANKL treatment of SERCA2(+/-) BMMs incompletely induced formation of multinucleated cells, leading to reduced bone resorption activity. These results suggest that RANKL-mediated induction of SERCA2 plays a critical role in the RANKL-induced [Ca(2+)](i) oscillations that are essential for osteoclastogenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1763~1769 | - |
dc.relation.isPartOf | JOURNAL OF BONE AND MINERAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Density/drug effects | - |
dc.subject.MESH | Bone Marrow Cells/cytology | - |
dc.subject.MESH | Calcium Signaling/drug effects | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Monocytes/drug effects | - |
dc.subject.MESH | Monocytes/enzymology | - |
dc.subject.MESH | Monocytes/pathology | - |
dc.subject.MESH | NFATC Transcription Factors/metabolism | - |
dc.subject.MESH | Osteoclasts/drug effects* | - |
dc.subject.MESH | Osteoclasts/enzymology* | - |
dc.subject.MESH | Osteoclasts/pathology | - |
dc.subject.MESH | Osteogenesis/drug effects* | - |
dc.subject.MESH | Osteopetrosis/enzymology | - |
dc.subject.MESH | Osteopetrosis/pathology | - |
dc.subject.MESH | Osteopetrosis/physiopathology | - |
dc.subject.MESH | Protein Transport/drug effects | - |
dc.subject.MESH | RANK Ligand/pharmacology* | - |
dc.subject.MESH | Sarcoplasmic Reticulum Calcium-Transporting ATPases/deficiency* | - |
dc.subject.MESH | Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism | - |
dc.title | Alteration of RANKL-induced osteoclastogenesis in primary cultured osteoclasts from SERCA2+/- mice | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Yu-Mi Yang | - |
dc.contributor.googleauthor | Min Seuk Kim | - |
dc.contributor.googleauthor | Aran Son | - |
dc.contributor.googleauthor | Jeong Hee Hong | - |
dc.contributor.googleauthor | Kyung-Ho Kim | - |
dc.contributor.googleauthor | Jeong Taeg Seo | - |
dc.contributor.googleauthor | Syng-Ill Lee | - |
dc.contributor.googleauthor | Dong Min Shin | - |
dc.identifier.doi | 10.1359/jbmr.090420 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00309 | - |
dc.contributor.localId | A01905 | - |
dc.contributor.localId | A01979 | - |
dc.contributor.localId | A02091 | - |
dc.contributor.localId | A02924 | - |
dc.contributor.localId | A04434 | - |
dc.relation.journalcode | J01278 | - |
dc.identifier.eissn | 1523-4681 | - |
dc.identifier.pmid | 19419309 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1359/jbmr.090420/abstract | - |
dc.subject.keyword | sarco/endoplasmic reticulum Ca2+ATPase | - |
dc.subject.keyword | RANKL | - |
dc.subject.keyword | oste oclastogenesis | - |
dc.subject.keyword | [Ca2+]i oscillation | - |
dc.subject.keyword | osteopetrosis | - |
dc.contributor.alternativeName | Kim, Kyung Ho | - |
dc.contributor.alternativeName | Seo, Jeong Taeg | - |
dc.contributor.alternativeName | Son, Seung Hwa | - |
dc.contributor.alternativeName | Shin, Dong Min | - |
dc.contributor.alternativeName | Lee, Syng Ill | - |
dc.contributor.alternativeName | Hong, Jeong Hee | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Ho | - |
dc.contributor.affiliatedAuthor | Seo, Jeong Taeg | - |
dc.contributor.affiliatedAuthor | Son, Seung Hwa | - |
dc.contributor.affiliatedAuthor | Shin, Dong Min | - |
dc.contributor.affiliatedAuthor | Lee, Syng Ill | - |
dc.contributor.affiliatedAuthor | Hong, Jeong Hee | - |
dc.citation.volume | 24 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1763 | - |
dc.citation.endPage | 1769 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BONE AND MINERAL RESEARCH, Vol.24(10) : 1763-1769, 2009 | - |
dc.identifier.rimsid | 52590 | - |
dc.type.rims | ART | - |
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