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Clinicopathological aspects and prognostic value with respect to age: an analysis of 3,362 consecutive gastric cancer patients

Authors
 JUN CHUL PARK  ;  YONG CHAN LEE  ;  JIE-HYUN KIM  ;  YU JIN KIM  ;  SANG KIL LEE  ;  WOO JIN HYUNG  ;  SUNG HOON NOH  ;  CHOONG BAI KIM 
Citation
 JOURNAL OF SURGICAL ONCOLOGY, Vol.99(7) : 395-401, 2009 
Journal Title
 JOURNAL OF SURGICAL ONCOLOGY 
ISSN
 0022-4790 
Issue Date
2009
MeSH
Adult ; Age Factors ; Aged ; Aged, 80 and over ; Databases, Factual ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging* ; Prognosis ; Retrospective Studies ; Stomach Neoplasms/diagnosis* ; Stomach Neoplasms/pathology* ; Stomach Neoplasms/surgery
Keywords
young age gastric cancer ; prognosis ; CA19-9
Abstract
BACKGROUND AND OBJECTIVES: Several studies have reported controversial results about clinicopathological features and prognoses in gastric cancer patients with respect to age, partly due to variable definitions of young age and inhomogeneity of the patient population. The aim of study was to analyze clinicopathological features and prognostic value of all stages of gastric cancer in a large consecutive series. METHODS: Between 2000 and 2005, 3,362 patients with all stages of gastric cancer were enrolled in database. Patients were divided into three groups: group 1 (< or =45), group 2 (46-70), and group 3 (> or =71). RESULTS: Upper location and linitis plastica were more frequent in group 1. Young patients had a higher proportion of poorly differentiated and signet ring cell type with elevated CA19-9 level. Depressed type was more frequent in early gastric cancer (EGC) while Bormann type IV and Lauren diffuse type were more common in AGC in group 1. In curatively resected patients, a 5-year survival rate was significantly higher in group 1 than older groups. Stage, vein invasion, curative resection, and CA19-9 level were significant prognostic factors in all gastric cancer. CONCLUSIONS: Clinicopathological features associated with young gastric cancer include upper location, linitis plastica, histopathologically diffuse type, and unresectability.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jso.21281/abstract
DOI
10.1002/jso.21281
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yoo Jin(김유진)
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Kim, Choong Bai(김충배)
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Park, Jun Chul(박준철) ORCID logo https://orcid.org/0000-0001-8018-0010
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104254
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