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Correlation of serum-soluble triggering receptor expressed on myeloid cells-1 with clinical disease activity in inflammatory bowel disease

Authors
 Jae Jun Park  ;  Jae Hee Cheon  ;  Bo Young Kim  ;  Duk Hwan Kim  ;  Eun Soo Kim  ;  Tae Il Kim  ;  Kyoung Ryul Lee  ;  Won Ho Kim 
Citation
 DIGESTIVE DISEASES AND SCIENCES, Vol.54(7) : 1525-1531, 2009 
Journal Title
DIGESTIVE DISEASES AND SCIENCES
ISSN
 0163-2116 
Issue Date
2009
MeSH
Adult ; Biomarkers/blood ; C-Reactive Protein/analysis ; Colitis, Ulcerative/blood* ; Crohn Disease/blood* ; Female ; Humans ; Male ; Membrane Glycoproteins/blood* ; Multivariate Analysis ; Myeloid Cells/metabolism* ; ROC Curve ; Receptors, Immunologic/blood* ; Sensitivity and Specificity ; Severity of Illness Index ; Triggering Receptor Expressed on Myeloid Cells-1 ; Up-Regulation/physiology
Keywords
Triggering receptor expressed on myeloid cells-1 ; Ulcerative colitis ; Crohn’s disease ; Disease activity
Abstract
Although triggering receptor expressed on myeloid cells-1 (TREM-1) has recently been shown to be upregulated in the intestines of patients with inflammatory bowel disease (IBD), it remains unclear whether serum-soluble TREM-1 (sTREM-1) level reflects disease activity in patients with IBD. This study aimed to evaluate the correlation of sTREM-1 level with disease activity in IBD. We prospectively enrolled consecutive patients with IBD and assessed their clinical disease activity using the guidelines of the American College of Gastroenterology. At the time that disease activity was assessed, sTREM-1 level (using an enzyme-linked immunosorbent assay method) and other laboratory findings including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were also measured. A total of 31 patients with ulcerative colitis (UC) and 22 with Crohn's disease (CD) were enrolled. The mean sTREM-1 level in patients with either UC (60.4 +/- 41.8 pg/ml) or CD (66.5 +/- 42.4 pg/ml) was significantly higher than in healthy controls (0.6 +/- 1.4 pg/ml) (P = 0.003 and P = 0.002, respectively). In patients with UC, sTREM-1 level was more highly correlated with disease activity (r = 0.849) than was ESR (r = 0.619) or CRP level (r = 0.546). Moreover, sTREM-1 level correlated well with disease activity irrespective of disease extent. In patients with CD, sTREM-1 level was lower in those with remission compared with those without (46.8 +/- 35.3 pg/ml versus 77.8 +/- 43.1 pg/ml), but this trend did not reach statistical significance (P = 0.100). The results of our study suggest that sTREM-1 could be a potential marker for disease activity in IBD patients, especially those with UC.
Full Text
http://link.springer.com/article/10.1007%2Fs10620-008-0514-5
DOI
10.1007/s10620-008-0514-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Duk Hwan(김덕환)
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Eun Soo(김은수)
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Park, Jae Jun(박재준)
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104253
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