Cited 70 times in

Correlation of serum-soluble triggering receptor expressed on myeloid cells-1 with clinical disease activity in inflammatory bowel disease

DC Field Value Language
dc.contributor.author김태일-
dc.contributor.author박재준-
dc.contributor.author천재희-
dc.contributor.author김덕환-
dc.contributor.author김원호-
dc.contributor.author김은수-
dc.date.accessioned2015-04-24T16:49:50Z-
dc.date.available2015-04-24T16:49:50Z-
dc.date.issued2009-
dc.identifier.issn0163-2116-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104253-
dc.description.abstractAlthough triggering receptor expressed on myeloid cells-1 (TREM-1) has recently been shown to be upregulated in the intestines of patients with inflammatory bowel disease (IBD), it remains unclear whether serum-soluble TREM-1 (sTREM-1) level reflects disease activity in patients with IBD. This study aimed to evaluate the correlation of sTREM-1 level with disease activity in IBD. We prospectively enrolled consecutive patients with IBD and assessed their clinical disease activity using the guidelines of the American College of Gastroenterology. At the time that disease activity was assessed, sTREM-1 level (using an enzyme-linked immunosorbent assay method) and other laboratory findings including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were also measured. A total of 31 patients with ulcerative colitis (UC) and 22 with Crohn's disease (CD) were enrolled. The mean sTREM-1 level in patients with either UC (60.4 +/- 41.8 pg/ml) or CD (66.5 +/- 42.4 pg/ml) was significantly higher than in healthy controls (0.6 +/- 1.4 pg/ml) (P = 0.003 and P = 0.002, respectively). In patients with UC, sTREM-1 level was more highly correlated with disease activity (r = 0.849) than was ESR (r = 0.619) or CRP level (r = 0.546). Moreover, sTREM-1 level correlated well with disease activity irrespective of disease extent. In patients with CD, sTREM-1 level was lower in those with remission compared with those without (46.8 +/- 35.3 pg/ml versus 77.8 +/- 43.1 pg/ml), but this trend did not reach statistical significance (P = 0.100). The results of our study suggest that sTREM-1 could be a potential marker for disease activity in IBD patients, especially those with UC.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1525~1531-
dc.relation.isPartOfDIGESTIVE DISEASES AND SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHC-Reactive Protein/analysis-
dc.subject.MESHColitis, Ulcerative/blood*-
dc.subject.MESHCrohn Disease/blood*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMembrane Glycoproteins/blood*-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHMyeloid Cells/metabolism*-
dc.subject.MESHROC Curve-
dc.subject.MESHReceptors, Immunologic/blood*-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHTriggering Receptor Expressed on Myeloid Cells-1-
dc.subject.MESHUp-Regulation/physiology-
dc.titleCorrelation of serum-soluble triggering receptor expressed on myeloid cells-1 with clinical disease activity in inflammatory bowel disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJae Jun Park-
dc.contributor.googleauthorJae Hee Cheon-
dc.contributor.googleauthorBo Young Kim-
dc.contributor.googleauthorDuk Hwan Kim-
dc.contributor.googleauthorEun Soo Kim-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorKyoung Ryul Lee-
dc.contributor.googleauthorWon Ho Kim-
dc.identifier.doi10.1007/s10620-008-0514-5-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01079-
dc.contributor.localIdA01636-
dc.contributor.localIdA00377-
dc.contributor.localIdA00774-
dc.contributor.localIdA00804-
dc.contributor.localIdA04030-
dc.relation.journalcodeJ00737-
dc.identifier.eissn1573-2568-
dc.identifier.pmid18975078-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs10620-008-0514-5-
dc.subject.keywordTriggering receptor expressed on myeloid cells-1-
dc.subject.keywordUlcerative colitis-
dc.subject.keywordCrohn’s disease-
dc.subject.keywordDisease activity-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNamePark, Jae Jun-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.alternativeNameKim, Duk Hwan-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.alternativeNameKim, Eun Soo-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorPark, Jae Jun-
dc.contributor.affiliatedAuthorKim, Duk Hwan-
dc.contributor.affiliatedAuthorKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Eun Soo-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.citation.volume54-
dc.citation.number7-
dc.citation.startPage1525-
dc.citation.endPage1531-
dc.identifier.bibliographicCitationDIGESTIVE DISEASES AND SCIENCES, Vol.54(7) : 1525-1531, 2009-
dc.identifier.rimsid56143-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.