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Comprehensive clinical follow-up of late effects in childhood cancer survivors shows the need for early and well-timed intervention.

 J. W. Han  ;  S. Y. Kwon  ;  S. C. Won  ;  Y. J. Shin  ;  J. H. Ko  ;  C. J. Lyu 
 ANNALS OF ONCOLOGY, Vol.20(7) : 1170-1177, 2009 
Journal Title
Issue Date
Adaptation, Psychological ; Adolescent ; Adult ; Age of Onset ; Antineoplastic Agents/adverse effects ; Asian Continental Ancestry Group ; Child ; Child, Preschool ; Continuity of Patient Care ; Endocrine System/physiopathology ; Female ; Follow-Up Studies ; Humans ; Korea ; Male ; Needs Assessment ; Neoplasms/ethnology ; Neoplasms/therapy* ; Quality of Life/psychology* ; Radiation Injuries ; Risk ; Survivors/psychology* ; Time Factors ; Young Adult
cancer ; childhood cancer ; late effect ; survivor
BACKGROUND: Due to recent advances in treatment, nearly 80% of childhood cancer patients become long-term survivors. Studies on the late effects of survivors are under way worldwide. However, data on Asian survivors remain limited. METHODS: Data on 241 survivors at the Long-term Follow-up Clinic in Severance Hospital, South Korea, were collected and late effects were confirmed by oncologists. RESULTS: The median follow-up from diagnosis was 7.8 years. Late effects were identified in 59.8% of survivors and 23.2% had two or more late effects. Grade 3 or higher late effects were present in 10.8%. The most common late effects involved endocrine system (29.0%). Late effects were present in 95.7% of brain tumor survivors and 36.0% of Wilms' tumor survivors. Chemotherapy, hematopoietic stem-cell transplantation and radiotherapy were significant factors associated with the number and severity of late effects (P < 0.05). Brain tumor survivors had more severe late effects (P < 0.001), whereas Wilms' tumor survivors had fewer and milder late effects (P < 0.05). CONCLUSION: The observation that over 50% of cancer survivors suffered from late effects during the short follow-up period and that a high frequency of endocrine late effects was present indicates the need for early and well-timed intervention of the survivors.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
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