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Comprehensive clinical follow-up of late effects in childhood cancer survivors shows the need for early and well-timed intervention.

DC FieldValueLanguage
dc.contributor.author유철주-
dc.date.accessioned2015-04-24T16:49:47Z-
dc.date.available2015-04-24T16:49:47Z-
dc.date.issued2009-
dc.identifier.issn0923-7534-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104251-
dc.description.abstractBACKGROUND: Due to recent advances in treatment, nearly 80% of childhood cancer patients become long-term survivors. Studies on the late effects of survivors are under way worldwide. However, data on Asian survivors remain limited. METHODS: Data on 241 survivors at the Long-term Follow-up Clinic in Severance Hospital, South Korea, were collected and late effects were confirmed by oncologists. RESULTS: The median follow-up from diagnosis was 7.8 years. Late effects were identified in 59.8% of survivors and 23.2% had two or more late effects. Grade 3 or higher late effects were present in 10.8%. The most common late effects involved endocrine system (29.0%). Late effects were present in 95.7% of brain tumor survivors and 36.0% of Wilms' tumor survivors. Chemotherapy, hematopoietic stem-cell transplantation and radiotherapy were significant factors associated with the number and severity of late effects (P < 0.05). Brain tumor survivors had more severe late effects (P < 0.001), whereas Wilms' tumor survivors had fewer and milder late effects (P < 0.05). CONCLUSION: The observation that over 50% of cancer survivors suffered from late effects during the short follow-up period and that a high frequency of endocrine late effects was present indicates the need for early and well-timed intervention of the survivors.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1170~1177-
dc.relation.isPartOfANNALS OF ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdaptation, Psychological-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAge of Onset-
dc.subject.MESHAntineoplastic Agents/adverse effects-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHContinuity of Patient Care-
dc.subject.MESHEndocrine System/physiopathology-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHMale-
dc.subject.MESHNeeds Assessment-
dc.subject.MESHNeoplasms/ethnology-
dc.subject.MESHNeoplasms/therapy*-
dc.subject.MESHQuality of Life/psychology*-
dc.subject.MESHRadiation Injuries-
dc.subject.MESHRisk-
dc.subject.MESHSurvivors/psychology*-
dc.subject.MESHTime Factors-
dc.subject.MESHYoung Adult-
dc.titleComprehensive clinical follow-up of late effects in childhood cancer survivors shows the need for early and well-timed intervention.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorJ. W. Han-
dc.contributor.googleauthorS. Y. Kwon-
dc.contributor.googleauthorS. C. Won-
dc.contributor.googleauthorY. J. Shin-
dc.contributor.googleauthorJ. H. Ko-
dc.contributor.googleauthorC. J. Lyu-
dc.identifier.doi10.1093/annonc/mdn778-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02524-
dc.relation.journalcodeJ00171-
dc.identifier.eissn1569-8041-
dc.identifier.pmid19270031-
dc.subject.keywordcancer-
dc.subject.keywordchildhood cancer-
dc.subject.keywordlate effect-
dc.subject.keywordsurvivor-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.affiliatedAuthorLyu, Chuhl Joo-
dc.citation.volume20-
dc.citation.number7-
dc.citation.startPage1170-
dc.citation.endPage1177-
dc.identifier.bibliographicCitationANNALS OF ONCOLOGY, Vol.20(7) : 1170-1177, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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