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Chronic myelomonocytic leukemia with der(9)t(1;9)(q11;q34) as a sole abnormality

Authors
 Borum Suh  ;  Tae Sung Park  ;  Jin Seok Kim  ;  Jaewoo Song  ;  Juwon Kim  ;  Jong-Ha Yoo  ;  Jong Rak Choi 
Citation
 ANNALS OF CLINICAL AND LABORATORY SCIENCE, Vol.39(3) : 307-312, 2009 
Journal Title
 ANNALS OF CLINICAL AND LABORATORY SCIENCE 
ISSN
 0091-7370 
Issue Date
2009
MeSH
Bone Marrow Cells/pathology ; Chromosome Aberrations* ; Chromosome Painting ; Chromosomes, Human, Pair 1/genetics ; Chromosomes, Human, Pair 9/genetics ; Humans ; Karyometry ; Leukemia, Myelomonocytic, Chronic/drug therapy ; Leukemia, Myelomonocytic, Chronic/genetics* ; Leukemia, Myelomonocytic, Chronic/pathology ; Leukocytes/pathology ; Male ; Metaphase/genetics ; Middle Aged ; Translocation, Genetic/genetics ; Trisomy/genetics
Keywords
der(9)t(1 ; 9)(q11 ; q34) ; CMML ; mFISH ; monocytic-lineage leukemia
Abstract
The chromosomal abnormality der(9)t(1;9)(q11;q34) is a rare occurrence in patients with hematologic malignancies. As far as we know, only 3 cases of acute myeloid leukemia, 1 case of polycythemia vera, and 1 case of multiple myeloma with this derivative chromosome have been reported in the literature. Here we report the first case of der(9)t(1;9)(q11;q34) in a patient with chronic myelomonocytic leukemia (CMML). A 45-yr-old man was brought to our hospital for evaluation of pancytopenia and monocytosis. The patient's persistent monocytosis in peripheral blood and his bone marrow findings were consistent with the diagnosis of CMML. Chromosome study results repeatedly showed 46,XY,der(9)t(1;9)(q11;q34). In addition, the BCR/ABL fluorescent in situ hybridization (FISH) pattern of the interphase cells was interpreted as: "nuc ish(ABL, BCR) x 2[292/300]," consistent with the normal signal patterns found in 97% of the nuclei examined. For further evaluation, multi-color FISH (mFISH) analysis was performed and it showed the distinct unbalanced derivative chromosome der(9)t(1;9)(q11;q34) in 5 metaphase cells analyzed. Not only does this show an extraordinary type of trisomy 1q, but it reveals a rare recurrent case of der(9)t(1;9)(q11;q34) in patients with monocytic-lineage leukemia. Further studies are needed to evaluate the prognosis, survival, and treatment response of such patients with der(9)t(1;9)(q11;q34).
Full Text
http://www.annclinlabsci.org/content/39/3/307.long
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Park, Tae Sung(박태성)
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104209
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