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Level of vascular endothelial growth factor in aqueous humor and surgical results of ahmed glaucoma valve implantation in patients with neovascular glaucoma.

 Yong Guk Kim  ;  Samin Hong  ;  Christopher Seungkyu Lee  ;  Sung Yong Kang  ;  Gong Je Seong  ;  Kyoung Tak Ma  ;  Chan Yun Kim 
 JOURNAL OF GLAUCOMA, Vol.18(6) : 443-447, 2009 
Journal Title
Issue Date
Adult ; Aged ; Aqueous Humor/metabolism* ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Glaucoma Drainage Implants* ; Glaucoma, Neovascular/etiology ; Glaucoma, Neovascular/metabolism* ; Glaucoma, Neovascular/surgery* ; Humans ; Intraocular Pressure ; Male ; Middle Aged ; Prosthesis Implantation ; Transforming Growth Factor beta1/metabolism ; Transforming Growth Factor beta2/metabolism ; Treatment Outcome ; Vascular Endothelial Growth Factor A/metabolism*
Ahmed glaucoma valve ; aqueous humor ; neovascular glaucoma ; vascular endothelial growth factor
PURPOSE: To determine the associations between the levels of growth factors in aqueous humor and the surgical outcomes of Ahmed glaucoma valve implantation in patients with neovascular glaucoma (NVG).

METHODS: From 19 NVG eyes of 19 patients, a sample of aqueous humor was taken just before Ahmed glaucoma valve implantation. Levels of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-beta1, and TGF-beta2 in aqueous humor aspirates were measured using a sandwich enzyme-linked immunosorbent assay method. When the postoperative intraocular pressures were >or=21 mm Hg with or without antiglaucoma medications at 2 successive visits or when any other surgical interventions were needed to lower intraocular pressure, that surgery was considered a failure. After patients were classified into success versus failure groups, the levels of the growth factors between the 2 groups was compared. The cumulative probability of success according to Kaplan-Meier analysis was also determined.

RESULTS: Mean postoperative follow-up period was 40.9+/-19.6 months and cumulative probability of success was 43% at 57 months after surgery. Mean VEGF level in the failure group was higher than that of the success group (P=0.014). However, there was no statistical difference in the levels of TGF-beta1, TGF-beta2, and protein between 2 study groups (all P>0.05).

CONCLUSIONS: The level of VEGF in aqueous humor was significantly higher in the failure group after the Ahmed glaucoma implantation compared with the success group. Our results imply that VEGF may play a role in determining surgical success after Ahmed valve implantation in patients with NVG.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sung Yong(강성용)
Kim, Yong Guk(김용국)
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Ma, Kyung Tak(마경탁)
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
Hong, Sa Min(홍사민)
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