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Hepatic fibrosis scan for liver stiffness score measurement: a useful preendoscopic screening test for the detection of varices in postoperative patients with biliary atresia

Authors
 Hye Kyung Chang  ;  Youn Joon Park  ;  Hong Koh  ;  Seong Min Kim  ;  Ki Sup Chung  ;  Jung Tak Oh  ;  Seok Joo Han 
Citation
 JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, Vol.49(3) : 323-328, 2009 
Journal Title
 JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION 
ISSN
 0277-2116 
Issue Date
2009
MeSH
Biliary Atresia/complications* ; Biliary Atresia/surgery ; Child, Preschool ; Elastic Modulus ; Esophageal and Gastric Varices/diagnosis* ; Esophageal and Gastric Varices/etiology ; Female ; Humans ; Hypertension, Portal/etiology ; Infant ; Liver/pathology* ; Liver/surgery ; Liver Cirrhosis/diagnosis* ; Male ; Portoenterostomy, Hepatic ; Postoperative Complications/diagnosis* ; Reference Values ; Sensitivity and Specificity
Keywords
Biliary atresia ; Esophageal varices ; FibroScan ; Gastric varices ; Liver stiffness
Abstract
OBJECTIVE: Even after successful Kasai portoenterostomy, progressive hepatic fibrosis in postoperative patients with biliary atresia (BA) can be associated with portal hypertension and esophageal or gastric varices. Therefore, early diagnosis and close follow-up of varices are important. We investigated the correlation between the liver stiffness scores measured by FibroScan and the presence of esophageal or gastric varices to examine the usefulness of FibroScan as a preendoscopic screening test for varices. PATIENTS AND METHODS: A total of 49 of 81 children with BA following successful Kasai operations were enrolled in this study. FibroScan and endoscopic examination were performed prospectively. RESULTS: There were 22 males (44.9%) and the mean age of the patients was 3.8 +/- 2.7 years. Esophageal or gastric varices were present in 30 patients (Vx group) and absent in 19 (nVx group). The mean liver stiffness score was significantly higher in the Vx group (21.35 +/- 10.31 kPa in the Vx group versus 9.75 +/- 8.61 kPa in the nVx group, P < 0.001). The optimal cutoff value of the liver stiffness score for the prediction of a varix was 9.7 kPa with a sensitivity of 0.97 and a specificity of 0.80. CONCLUSIONS: Liver stiffness scores measured by FibroScan correlate well with the presence of esophageal or gastric varices. FibroScan is a novel, noninvasive, and useful screening method for the preendoscopic detection of varices in postoperative patients with BA.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00005176-200909000-00010&LSLINK=80&D=ovft
DOI
10.1097/MPG.0b013e31819de7ba
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hong(고홍) ORCID logo https://orcid.org/0000-0002-3660-7483
Kim, Seong Min(김성민)
Oh, Jung Tak(오정탁)
Chang, Hye Kyung(장혜경)
Chung, Ki Sup(정기섭)
Han, Seok Joo(한석주) ORCID logo https://orcid.org/0000-0001-5224-1437
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104135
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