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이차 관해 후 Gemtuzumab Ozogamicin (MylotargⓇ) 단독 공고요법으로 장기 무질병 생존 중인 급성골수구성백혈병 1례: 종교적인 이유로 수혈과 조혈모세포 이식이 불가능하였던 예

Other Titles
 Gemtuzumab Ozogamicin (MylotargⓇ) as a Single Consolidation Therapy in Relapsed Pediatric Acute Myeloid Leukemia Patient: a Patient Who Refused Transfusion and Stem Cell Transplantation for Religious Belief 
Authors
 이하늘  ;  김효선  ;  권승연  ;  원성철  ;  김범식  ;  최성열  ;  양우익  ;  유철주 
Citation
 Clinical Pediatric Hematology-Oncology (임상소아혈액종양), Vol.16(1) : 59-64, 2009 
Journal Title
 Clinical Pediatric Hematology-Oncology (임상소아혈액종양) 
ISSN
 1225-6978 
Issue Date
2009
Keywords
Pediatric ; Acute myeloid leukemia ; Gemtuzumab ozogamicin ; Mylotarg
Abstract
Despite improvement of long-term survival rate in pediatric acute myeloid leukemia (AML) during the last two decades, relapse/refractory disease remains a major obstacle to further improvement of prognosis. Moreover, there are only few therapeutic options which stimulate investigations for targeted, less toxic therapy. Gemtuzumab ozogamicin (GO, MylotargⓇ) is an anti-CD33 monoclonal antibody and there are ongoing studies evaluating safety and efficacy of this drug in relapsed/refractory AML patients. Still, the response rate is only 30% and the response does not last more than a year. We present a case of pediatric central nervous system relapsed AML who was treated with GO as a single consolidation therapy without stem cell transplantation because of religious belief and maintained CR status for more than 3 years.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Seung Yeon(권승연)
Kim, Hyo Sun(김효선)
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Won, Sung Chul(원성철)
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104111
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