Cited 62 times in
A smart flower-like polymeric micelle for pH-triggered anticancer drug release.
DC Field | Value | Language |
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dc.contributor.author | 오영택 | - |
dc.date.accessioned | 2015-04-24T16:44:42Z | - |
dc.date.available | 2015-04-24T16:44:42Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104091 | - |
dc.description.abstract | Novel pH-responsive flower-like micelles were developed to provide the mechanism for pH-triggered drug release from drug carriers. The micelles (particle size: approximately 165 nm; critical micelle concentration (CMC): approximately 4 microg/ml), constructed from poly(N(epsilon)-(3-diethylamino)propyl isothiocyanato-L-lysine)-b-poly(ethylene glycol)-b-poly(L-lactide) [poly(DEAP-Lys)-b-PEG-b-PLLA], were designed to have a self-assembled flower-like arrangement consisting of two hydrophobic blocks [deprotonated poly(DEAP-Lys) block and PLLA block] and a petal-like hydrophilic PEG block at physiological pH. As the pH decreases to slightly acidic pH (<pH 7.0), as in tumor extracellular pH (pH(e)), the flower-like micelles undergo a change in the hydrophobicity of the micellar core. The protonation of poly(DEAP-Lys) changed the physical property of the polymer from hydrophobic to hydrophilic, resulting in disintegration of the micellar core. The co-presence of a pH-insensitive PLLA block in the micellar core affected the protonation of poly(DEAP-Lys), allowing the micelle to be stable at pH 7.0-7.4. In this study using doxorubicin (DOX) as the model drug, DOX release from the micelles accelerated in response to tumor pH(e). | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 163~169 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antibiotics, Antineoplastic/administration & dosage* | - |
dc.subject.MESH | Antibiotics, Antineoplastic/chemistry | - |
dc.subject.MESH | Doxorubicin/administration & dosage* | - |
dc.subject.MESH | Doxorubicin/chemistry | - |
dc.subject.MESH | Drug Delivery Systems | - |
dc.subject.MESH | Hydrogen-Ion Concentration | - |
dc.subject.MESH | Hydrophobic and Hydrophilic Interactions | - |
dc.subject.MESH | Lactic Acid/chemistry | - |
dc.subject.MESH | Micelles | - |
dc.subject.MESH | Neoplasms/drug therapy | - |
dc.subject.MESH | Neoplasms/pathology | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Polyesters | - |
dc.subject.MESH | Polyethylene Glycols/chemistry | - |
dc.subject.MESH | Polymers/chemistry* | - |
dc.title | A smart flower-like polymeric micelle for pH-triggered anticancer drug release. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Kyung Taek Oh | - |
dc.contributor.googleauthor | Young Taik Oh | - |
dc.contributor.googleauthor | Nam-Muk Oh | - |
dc.contributor.googleauthor | Kwangmyung Kim | - |
dc.contributor.googleauthor | Don Haeng Lee | - |
dc.contributor.googleauthor | Eun Seong Lee | - |
dc.identifier.doi | 10.1016/j.ijpharm.2009.04.005 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02390 | - |
dc.relation.journalcode | J01150 | - |
dc.identifier.eissn | 1873-3476 | - |
dc.identifier.pmid | 19481702 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0378517309001926 | - |
dc.subject.keyword | pH-sensitive flower-like micelle | - |
dc.subject.keyword | 3-Diethylamino propyl isothiocyanato-l-lysine | - |
dc.subject.keyword | pH-dependent drug release | - |
dc.subject.keyword | Tumor targeting | - |
dc.contributor.alternativeName | Oh, Young Taik | - |
dc.contributor.affiliatedAuthor | Oh, Young Taik | - |
dc.citation.volume | 375 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 163 | - |
dc.citation.endPage | 169 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol.375(1-2) : 163-169, 2009 | - |
dc.identifier.rimsid | 54537 | - |
dc.type.rims | ART | - |
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