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A fluorescent polymer for patterning of mesenchymal stem cells

Authors
 Jungmok You  ;  June Seok Heo  ;  Jiyea Lee  ;  Han-Soo Kim  ;  Hyun Ok Kim  ;  Eunkyoung Kim 
Citation
 Macromolecules, Vol.42(9) : 3326-3332, 2009 
Journal Title
 Macromolecules 
ISSN
 0024-9297 
Issue Date
2009
Abstract
UV exposure of a fluorescent polymer, diphenylamino-s-triazine bridged p-phenylene vinylene polymer (DTOPV), resulted in fluorescence quenching and a change in surface wettability via photo-oxidation. Patterned polymer films were prepared simply by exposing the polymer film to UV source through a photomask under air. The UV-exposed region was highly biocompatible and provided selective mesenchymal stem cells (MSCs) attachment on it. This allowed cell alignment and patterning along the line patterns of linear, curved, and even various letter shapes. The proliferation rate of MSCs cultured on UV exposed surface (DTOPV+UV) was higher than that of the unexposed surface, and the cells were increased to10-fold after 6 days. The attachment of MSCs was highly selective to the UV-exposed pattern in the presence of collagen and gelatin, which induced cell patterning and attachment through hydrophilic interaction with the UV exposed area. Taking advantage of the emission from the DTOPV pattern, the cell location and pattern images were easily detected through a microscope with or without an excitation probe beam. These studies provide an exciting opportunity for novel cell patterning by a simple photopatterning process using a highly fluorescent DTOPV.
Full Text
http://pubs.acs.org/doi/abs/10.1021/ma802722q
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Han Soo(김한수)
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104035
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