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Prediction of parathyroid hormone signalling potency using SVMs

Authors
 Ahrim Yoo  ;  Sunggeon Ko  ;  Sung-Kil Lim  ;  Weontae Lee  ;  Dae Ryook Yang 
Citation
 Molecules and Cells, Vol.27(5) : 547-556, 2009 
Journal Title
 Molecules and Cells 
ISSN
 1016-8478 
Issue Date
2009
Abstract
Parathyroid hormone is the most important endocrine regulator of calcium concentration. Its N-terminal fragment (1-34) has sufficient activity for biological function. Recently, site-directed mutagenesis studies demonstrated that substitutions at several positions within shorter analogues (1-14) can enhance the bioactivity to greater than that of PTH (1-34). However, designing the optimal sequence combination is not simple due to complex combinatorial problems. In this study, support vector machines were introduced to predict the biological activity of modified PTH (1-14) analogues using mono-substituted experimental data and to analyze the key physicochemical properties at each position that correlated with bioactivity. This systematic approach can reduce the time and effort needed to obtain desirable molecules by bench experiments and provide useful information in the design of simpler activating molecules
Full Text
http://link.springer.com/article/10.1007%2Fs10059-009-0082-3
DOI
10.1007/s10059-009-0082-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
임승길(Lim, Sung Kil)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104034
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