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Prediction of parathyroid hormone signalling potency using SVMs
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임승길 | - |
dc.date.accessioned | 2015-04-24T16:42:53Z | - |
dc.date.available | 2015-04-24T16:42:53Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104034 | - |
dc.description.abstract | Parathyroid hormone is the most important endocrine regulator of calcium concentration. Its N-terminal fragment (1-34) has sufficient activity for biological function. Recently, site-directed mutagenesis studies demonstrated that substitutions at several positions within shorter analogues (1-14) can enhance the bioactivity to greater than that of PTH (1-34). However, designing the optimal sequence combination is not simple due to complex combinatorial problems. In this study, support vector machines were introduced to predict the biological activity of modified PTH (1-14) analogues using mono-substituted experimental data and to analyze the key physicochemical properties at each position that correlated with bioactivity. This systematic approach can reduce the time and effort needed to obtain desirable molecules by bench experiments and provide useful information in the design of simpler activating molecules | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 547~556 | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Calcium/chemistry | - |
dc.subject.MESH | Calcium/metabolism* | - |
dc.subject.MESH | Chemistry, Physical | - |
dc.subject.MESH | Computational Biology | - |
dc.subject.MESH | Computer Simulation* | - |
dc.subject.MESH | Cyclic AMP/chemistry | - |
dc.subject.MESH | Cyclic AMP/genetics | - |
dc.subject.MESH | Cyclic AMP/metabolism | - |
dc.subject.MESH | Endocrine System | - |
dc.subject.MESH | Genetic Engineering | - |
dc.subject.MESH | Genetic Vectors | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mutagenesis, Site-Directed | - |
dc.subject.MESH | Mutant Proteins/genetics | - |
dc.subject.MESH | Mutant Proteins/metabolism* | - |
dc.subject.MESH | Parathyroid Hormone/chemistry | - |
dc.subject.MESH | Parathyroid Hormone/genetics | - |
dc.subject.MESH | Parathyroid Hormone/metabolism* | - |
dc.subject.MESH | Peptide Fragments/chemistry | - |
dc.subject.MESH | Peptide Fragments/genetics | - |
dc.subject.MESH | Peptide Fragments/metabolism* | - |
dc.subject.MESH | Signal Transduction* | - |
dc.subject.MESH | Teriparatide/analogs & derivatives* | - |
dc.subject.MESH | Teriparatide/chemistry | - |
dc.subject.MESH | Teriparatide/metabolism | - |
dc.subject.MESH | Transcriptional Activation | - |
dc.title | Prediction of parathyroid hormone signalling potency using SVMs | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ahrim Yoo | - |
dc.contributor.googleauthor | Sunggeon Ko | - |
dc.contributor.googleauthor | Sung-Kil Lim | - |
dc.contributor.googleauthor | Weontae Lee | - |
dc.contributor.googleauthor | Dae Ryook Yang | - |
dc.identifier.doi | 10.1007/s10059-009-0082-3 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03375 | - |
dc.relation.journalcode | J02273 | - |
dc.identifier.eissn | 0219-1032 | - |
dc.identifier.pmid | 19466603 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10059-009-0082-3 | - |
dc.subject.keyword | function | - |
dc.subject.keyword | parathyroid hormone | - |
dc.subject.keyword | peptide analogue | - |
dc.subject.keyword | SVM | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Lim, Sung Kil | - |
dc.citation.volume | 27 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 547 | - |
dc.citation.endPage | 556 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, Vol.27(5) : 547-556, 2009 | - |
dc.identifier.rimsid | 46780 | - |
dc.type.rims | ART | - |
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