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Prediction of long-term outcome by percent improvement after the first day of thrombolytic treatment in stroke patients.
DC Field | Value | Language |
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dc.contributor.author | 남효석 | - |
dc.contributor.author | 안성환 | - |
dc.contributor.author | 이경열 | - |
dc.contributor.author | 이종윤 | - |
dc.contributor.author | 한상원 | - |
dc.contributor.author | 허지회 | - |
dc.contributor.author | 김동익 | - |
dc.contributor.author | 김동준 | - |
dc.contributor.author | 김서현 | - |
dc.contributor.author | 남정모 | - |
dc.date.accessioned | 2015-04-24T16:40:06Z | - |
dc.date.available | 2015-04-24T16:40:06Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0022-510X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103946 | - |
dc.description.abstract | BACKGROUND: We investigated a method for assessing early improvement and predictive factors of early and late outcomes in patients receiving thrombolytic therapy. METHODS: A total of 160 consecutive patients who received thrombolytic therapy were included in the study. Using National Institutes of Health Stroke Scale (NIHSS) scores, percent improvement [(baseline NIHSS score-24-hour NIHSS score)/baseline NIHSS score x 100] was calculated and compared with delta (baseline NIHSS score-24-hour NIHSS score) and with major neurological improvement (MNI, NIHSS score of 0-1 or >or=8 point improvement at 24 h) by receiver operating characteristic (ROC) curve analysis. Finally, we investigated the independent predictors of improvement at 24 h after the thrombolytic therapy and of favorable 3-month outcome (modified Rankin scale score 0-2). RESULTS: By pairwise comparison of ROC curves, percent improvement was stronger than delta (p=0.004) and MNI (p<0.001) in predicting long-term outcome. First day improvement (FDI), defined as greater than 20% improvement, was a strong predictor of favorable 3-month outcome (OR 12.55, 95% CI 5.41-29.10). Recanalization (OR 3.30, 95% CI 1.28-8.45), absence of carotid T occlusion (OR 0.09, 95% CI 0.02-0.42) and hemorrhagic transformation (OR 0.25, 95% CI 0.09-0.73) were independent predictors of FDI. Independent predictors of favorable 3-month outcome were FDI, current smoking, absence of carotid T occlusion and hemorrhagic transformation. CONCLUSIONS: Percent improvement at 24 h after thrombolytic therapy is a useful surrogate marker for predicting the long-term outcome. Our findings highlight the importance of early stroke managemen | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 69~73 | - |
dc.relation.isPartOf | JOURNAL OF THE NEUROLOGICAL SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Atrial Fibrillation/complications | - |
dc.subject.MESH | Carotid Artery Diseases/complications | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibrinolytic Agents/therapeutic use* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Injections, Intra-Arterial | - |
dc.subject.MESH | Injections, Intravenous | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Smoking | - |
dc.subject.MESH | Stroke/complications | - |
dc.subject.MESH | Stroke/drug therapy* | - |
dc.subject.MESH | Stroke/physiopathology | - |
dc.subject.MESH | Thrombolytic Therapy* | - |
dc.subject.MESH | Tissue Plasminogen Activator/therapeutic use* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Urokinase-Type Plasminogen Activator/therapeutic use* | - |
dc.title | Prediction of long-term outcome by percent improvement after the first day of thrombolytic treatment in stroke patients. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Hyo Suk Nam | - |
dc.contributor.googleauthor | Kyung-Yul Lee | - |
dc.contributor.googleauthor | Sang Won Han | - |
dc.contributor.googleauthor | Seo Hyun Kim | - |
dc.contributor.googleauthor | Jong Yun Lee | - |
dc.contributor.googleauthor | Seong Hwan Ahn | - |
dc.contributor.googleauthor | Dong Joon Kim | - |
dc.contributor.googleauthor | Dong Ik Kim | - |
dc.contributor.googleauthor | Chung Mo Nam | - |
dc.contributor.googleauthor | Ji Hoe Heo | - |
dc.identifier.doi | 10.1016/j.jns.2009.02.365 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01273 | - |
dc.contributor.localId | A02648 | - |
dc.contributor.localId | A03145 | - |
dc.contributor.localId | A04369 | - |
dc.contributor.localId | A00408 | - |
dc.contributor.localId | A00410 | - |
dc.contributor.localId | A00540 | - |
dc.contributor.localId | A01264 | - |
dc.contributor.localId | A04284 | - |
dc.contributor.localId | A02238 | - |
dc.relation.journalcode | J01897 | - |
dc.identifier.eissn | 1878-5883 | - |
dc.identifier.pmid | 19304298 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0022510X09004444 | - |
dc.subject.keyword | Ischemic stroke | - |
dc.subject.keyword | Thrombolysis | - |
dc.subject.keyword | Outcome | - |
dc.subject.keyword | ROC curve | - |
dc.contributor.alternativeName | Nam, Hyo Suk | - |
dc.contributor.alternativeName | An, Sung Whan | - |
dc.contributor.alternativeName | Lee, Kyung Yul | - |
dc.contributor.alternativeName | Lee, Jong Yun | - |
dc.contributor.alternativeName | Han, Sang Won | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.alternativeName | Kim, Dong Ik | - |
dc.contributor.alternativeName | Kim, Dong Joon | - |
dc.contributor.alternativeName | Kim, Seo Hyun | - |
dc.contributor.alternativeName | Nam, Jung Mo | - |
dc.contributor.affiliatedAuthor | Nam, Hyo Suk | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Yul | - |
dc.contributor.affiliatedAuthor | Lee, Jong Yun | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Kim, Dong Ik | - |
dc.contributor.affiliatedAuthor | Kim, Dong Joon | - |
dc.contributor.affiliatedAuthor | Kim, Seo Hyun | - |
dc.contributor.affiliatedAuthor | Nam, Jung Mo | - |
dc.contributor.affiliatedAuthor | Han, Sang Won | - |
dc.contributor.affiliatedAuthor | An, Sung Whan | - |
dc.citation.volume | 281 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 69 | - |
dc.citation.endPage | 73 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol.281(1-2) : 69-73, 2009 | - |
dc.identifier.rimsid | 37903 | - |
dc.type.rims | ART | - |
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