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Serum cholesterol levels and the risk of multiple system atrophy: a case-control study.

Authors
 Phil Hyu Lee  ;  Tae Sung Lim  ;  Hae-Won Shin  ;  Seok Woo Yong  ;  Hyo Suk Nam  ;  Young H. Sohn 
Citation
 MOVEMENT DISORDERS, Vol.24(5) : 752-758, 2009 
Journal Title
MOVEMENT DISORDERS
ISSN
 0885-3185 
Issue Date
2009
MeSH
Aged ; Case-Control Studies ; Cholesterol/blood* ; Cholesterol, HDL ; Cholesterol, LDL ; Female ; Humans ; Male ; Middle Aged ; Multiple System Atrophy/blood* ; Multiple System Atrophy/etiology ; Odds Ratio ; Retrospective Studies ; Risk Factors ; Severity of Illness Index ; Statistics as Topic
Keywords
multiple system atrophy ; total cholesterol ; HDL‐cholesterol
Abstract
Cholesterol in brain membranes may modulate the conformational state and accumulation of alpha-synuclein in alpha-synucleinopathies.We examined the association between serum cholesterol and the risk of multiple system atrophy (MSA), one of the alpha-synucleinopathies. We enrolled 142 patients with probable MSA from two tertiary referral hospitals and 155 age- and gender-matched healthy people with no neurological disease. The levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were significantly lower in MSA patients than in controls (total cholesterol: 172.7 vs. 196.3 mg/dL, P < 0.001; LDL-C: 104.0 vs. 115.3 mg/dL, P = 0.001; HDL-C: 47.3 vs. 54.2 mg/dL, P < 0.001). After adjusting for age, gender, use of cholesterol-lowering drugs, and histories of hypertension, diabetes mellitus, and smoking, the odds ratios was 5.9 (95% CI = 2.3-11.5, P < 0.001) for MSA patients in the lowest quartile of total cholesterol and 2.6 (95% CI = 1.2-5.5, P = 0.016) for those in the lowest quartile of HDL-C, compared with the highest quartiles. Levels of serum cholesterol did not significantly correlate with disease duration or severity. Our data suggest that lower levels of total cholesterol and HDL may be associated with an increased risk of MSA
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mds.22459/abstract
DOI
10.1002/mds.22459
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103891
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