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Cited 17 times in

Serum cholesterol levels and the risk of multiple system atrophy: a case-control study.

DC Field Value Language
dc.contributor.author남효석-
dc.contributor.author손영호-
dc.contributor.author이필휴-
dc.date.accessioned2015-04-24T16:38:19Z-
dc.date.available2015-04-24T16:38:19Z-
dc.date.issued2009-
dc.identifier.issn0885-3185-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103891-
dc.description.abstractCholesterol in brain membranes may modulate the conformational state and accumulation of alpha-synuclein in alpha-synucleinopathies.We examined the association between serum cholesterol and the risk of multiple system atrophy (MSA), one of the alpha-synucleinopathies. We enrolled 142 patients with probable MSA from two tertiary referral hospitals and 155 age- and gender-matched healthy people with no neurological disease. The levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were significantly lower in MSA patients than in controls (total cholesterol: 172.7 vs. 196.3 mg/dL, P < 0.001; LDL-C: 104.0 vs. 115.3 mg/dL, P = 0.001; HDL-C: 47.3 vs. 54.2 mg/dL, P < 0.001). After adjusting for age, gender, use of cholesterol-lowering drugs, and histories of hypertension, diabetes mellitus, and smoking, the odds ratios was 5.9 (95% CI = 2.3-11.5, P < 0.001) for MSA patients in the lowest quartile of total cholesterol and 2.6 (95% CI = 1.2-5.5, P = 0.016) for those in the lowest quartile of HDL-C, compared with the highest quartiles. Levels of serum cholesterol did not significantly correlate with disease duration or severity. Our data suggest that lower levels of total cholesterol and HDL may be associated with an increased risk of MSA-
dc.description.statementOfResponsibilityopen-
dc.format.extent752~758-
dc.relation.isPartOfMOVEMENT DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCholesterol/blood*-
dc.subject.MESHCholesterol, HDL-
dc.subject.MESHCholesterol, LDL-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultiple System Atrophy/blood*-
dc.subject.MESHMultiple System Atrophy/etiology-
dc.subject.MESHOdds Ratio-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHStatistics as Topic-
dc.titleSerum cholesterol levels and the risk of multiple system atrophy: a case-control study.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorTae Sung Lim-
dc.contributor.googleauthorHae-Won Shin-
dc.contributor.googleauthorSeok Woo Yong-
dc.contributor.googleauthorHyo Suk Nam-
dc.contributor.googleauthorYoung H. Sohn-
dc.identifier.doi10.1002/mds.22459-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01273-
dc.contributor.localIdA01982-
dc.contributor.localIdA03270-
dc.relation.journalcodeJ02275-
dc.identifier.eissn1531-8257-
dc.identifier.pmid19185013-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/mds.22459/abstract-
dc.subject.keywordmultiple system atrophy-
dc.subject.keywordtotal cholesterol-
dc.subject.keywordHDL‐cholesterol-
dc.contributor.alternativeNameNam, Hyo Suk-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.affiliatedAuthorNam, Hyo Suk-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.citation.volume24-
dc.citation.number5-
dc.citation.startPage752-
dc.citation.endPage758-
dc.identifier.bibliographicCitationMOVEMENT DISORDERS, Vol.24(5) : 752-758, 2009-
dc.identifier.rimsid37861-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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