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Prognostic significance of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma

Authors
 Hyo Sup Shim  ;  Bo Sung Yoon  ;  Nam Hoon Cho 
Citation
 Human Pathology, Vol.40(5) : 693-698, 2009 
Journal Title
 Human Pathology 
ISSN
 0046-8177 
Issue Date
2009
Abstract
This study was designed to investigate the prognostic significance of the expression of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma. The expression of epithelial cell adhesion molecule and E-cadherin was examined immunohistochemically on a tissue microarray of formalin-fixed paraffin-embedded tissue specimens from 72 consecutive patients. The overexpression of epithelial cell adhesion molecule was correlated with poor survival (P = .036). In contrast, the reduced expression of E-cadherin was correlated with poor survival (P = .034). When patients were subclassified into 4 groups according to positivity and negativity of epithelial cell adhesion molecule and E-cadherin expression, the epithelial cell adhesion molecule-positive E-cadherin-negative group showed the worst survival rate (P = .002, compared with the epithelial cell adhesion molecule-negative E-cadherin-positive group). These data suggest that the overexpression of epithelial cell adhesion molecule and reduced expression of E-cadherin in combination is more significant than a single marker for predicting poor survival.
Full Text
http://www.sciencedirect.com/science/article/pii/S0046817708005030
DOI
10.1016/j.humpath.2008.10.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Shim, Hyo Sup(심효섭) ORCID logo https://orcid.org/0000-0002-5718-3624
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103768
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