Cited 31 times in
Prognostic significance of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조남훈 | - |
dc.contributor.author | 심효섭 | - |
dc.date.accessioned | 2015-04-24T16:34:27Z | - |
dc.date.available | 2015-04-24T16:34:27Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0046-8177 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103768 | - |
dc.description.abstract | This study was designed to investigate the prognostic significance of the expression of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma. The expression of epithelial cell adhesion molecule and E-cadherin was examined immunohistochemically on a tissue microarray of formalin-fixed paraffin-embedded tissue specimens from 72 consecutive patients. The overexpression of epithelial cell adhesion molecule was correlated with poor survival (P = .036). In contrast, the reduced expression of E-cadherin was correlated with poor survival (P = .034). When patients were subclassified into 4 groups according to positivity and negativity of epithelial cell adhesion molecule and E-cadherin expression, the epithelial cell adhesion molecule-positive E-cadherin-negative group showed the worst survival rate (P = .002, compared with the epithelial cell adhesion molecule-negative E-cadherin-positive group). These data suggest that the overexpression of epithelial cell adhesion molecule and reduced expression of E-cadherin in combination is more significant than a single marker for predicting poor survival. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 693~698 | - |
dc.relation.isPartOf | HUMAN PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antigens, Neoplasm/biosynthesis* | - |
dc.subject.MESH | Biomarkers, Tumor/analysis* | - |
dc.subject.MESH | Cadherins/biosynthesis* | - |
dc.subject.MESH | Cell Adhesion Molecules/biosynthesis* | - |
dc.subject.MESH | Cystadenocarcinoma, Serous/metabolism* | - |
dc.subject.MESH | Cystadenocarcinoma, Serous/mortality | - |
dc.subject.MESH | Cystadenocarcinoma, Serous/pathology | - |
dc.subject.MESH | Epithelial Cell Adhesion Molecule | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Ovarian Neoplasms/metabolism* | - |
dc.subject.MESH | Ovarian Neoplasms/mortality | - |
dc.subject.MESH | Ovarian Neoplasms/pathology | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Tissue Array Analysis | - |
dc.title | Prognostic significance of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Hyo Sup Shim | - |
dc.contributor.googleauthor | Bo Sung Yoon | - |
dc.contributor.googleauthor | Nam Hoon Cho | - |
dc.identifier.doi | 10.1016/j.humpath.2008.10.013 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03812 | - |
dc.contributor.localId | A02219 | - |
dc.relation.journalcode | J01011 | - |
dc.identifier.eissn | 1532-8392 | - |
dc.identifier.pmid | 19157508 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0046817708005030 | - |
dc.subject.keyword | Ovarian serous carcinoma | - |
dc.subject.keyword | Epithelial cell adhesion molecule | - |
dc.subject.keyword | E-cadherin | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.alternativeName | Shim, Hyo Sup | - |
dc.contributor.affiliatedAuthor | Cho, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Shim, Hyo Sup | - |
dc.citation.volume | 40 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 693 | - |
dc.citation.endPage | 698 | - |
dc.identifier.bibliographicCitation | HUMAN PATHOLOGY, Vol.40(5) : 693-698, 2009 | - |
dc.identifier.rimsid | 36681 | - |
dc.type.rims | ART | - |
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