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Medial prefrontal default-mode hypoactivity affecting trait physical anhedonia in schizophrenia

Authors
 Il Ho Park  ;  Jae-Jin Kim  ;  Jiwon Chun  ;  Young Chul Jung  ;  Jeong Ho Seok  ;  Hae-Jeong Park  ;  Jong Doo Lee 
Citation
 PSYCHIATRY RESEARCH, Vol.171(3) : 155-165, 2009 
Journal Title
 PSYCHIATRY RESEARCH 
ISSN
 0165-1781 
Issue Date
2009
MeSH
Adult ; Affect/physiology ; Affective Symptoms/diagnostic imaging* ; Energy Metabolism/physiology* ; Female ; Fluorodeoxyglucose F18 ; Humans ; Image Processing, Computer-Assisted* ; Imaging, Three-Dimensional* ; Male ; Personality Inventory ; Positron-Emission Tomography* ; Prefrontal Cortex/diagnostic imaging* ; Psychiatric Status Rating Scales ; Schizophrenia/diagnostic imaging* ; Schizophrenic Psychology
Keywords
Anhedonia ; Dorsomedial prefrontal cortex ; Ventromedial prefrontal cortex ; Cerebellum ; FDG-PET ; Schizophrenia
Abstract
Anhedonia, as a deficit symptom, may be associated with default-mode hypofrontality in schizophrenia. To explore whether trait anhedonia in schizophrenia pertains to altered hypofrontal resting state brain function, resting state metabolic activities were compared and correlated with the Physical and Social Anhedonia Scale scores in 29 patients with schizophrenia and 21 healthy controls using (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET). In patients with schizophrenia, Physical Anhedonia Scale scores showed a trend-level negative correlation with the hypoactive dorsomedial prefrontal metabolism while Positive and Negative Symptom Scale (PANSS) negative subscale scores positively correlated with hyperactive cerebellar metabolism. Voxelwise correlation analysis showed physical anhedonia correlates in resting state activities of the supplementary motor area, ventromedial and dorsolateral prefrontal cortex, insular gyrus, and the precuneus in patients with schizophrenia while no frontal metabolic correlates were found in healthy controls. The hypoactive dorsomedial prefrontal metabolism correlated with physical anhedonia-correlated resting state regional activities. These findings provide further evidence for the relation of functional hypofrontality to the deficit syndrome and possible involvement of the functional imbalance in the cortico-cerebellar-thalamic-cortical circuit in the resting state brain function of schizophrenia.
Full Text
http://www.sciencedirect.com/science/article/pii/S0925492708000553
DOI
10.1016/j.pscychresns.2008.03.010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Il Ho(박일호)
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
Lee, Jong Doo(이종두)
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103603
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