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Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast

Authors
 Yup Kang  ;  Jang Hee Kim  ;  Tae Hui Lee  ;  Tai Seung Kim  ;  Woo Hee Jung  ;  Hyun Cheol Chung  ;  Byeong Woo Park  ;  Seung Soo Sheen  ;  Jae Ho Han 
Citation
 HUMAN PATHOLOGY, Vol.40(1) : 98-107, 2009 
Journal Title
 HUMAN PATHOLOGY 
ISSN
 0046-8177 
Issue Date
2009
MeSH
Adolescent ; Adult ; Anaphase-Promoting Complex-Cyclosome ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism* ; Breast Neoplasms/pathology ; Child ; Child, Preschool ; Female ; Fibroadenoma/genetics ; Fibroadenoma/metabolism* ; Fibroadenoma/pathology ; Flow Cytometry ; Gene Expression Regulation, Neoplastic* ; Humans ; Immunohistochemistry ; Ki-67 Antigen/metabolism ; Middle Aged ; Phyllodes Tumor/genetics ; Phyllodes Tumor/metabolism* ; Phyllodes Tumor/pathology ; Retrospective Studies ; S Phase ; Ubiquitin-Protein Ligase Complexes/genetics ; Ubiquitin-Protein Ligase Complexes/metabolism* ; Young Adult
Keywords
Anaphase-promoting complex ; Ki-67 ; Phyllodes tumor ; Fibroadenoma
Abstract
The proteolytic destruction of cyclin B is an important event during cell division. Cyclin B proteolysis is triggered by the anaphase-promoting complex. Therefore, cell cycle dysregulation due to anaphase-promoting complex loss contributes to cell transformation and human carcinogenesis. This study investigates anaphase-promoting complex7 expression in spindle cell breast tumors and also includes a comparison between the proliferation antigen Ki-67 and S-phase fraction. the average values of the anaphase-promoting complex7 and Ki-67 labeling indices increased in order from benign to malignant within the phyllodes tumor group, and the fibroadenoma and juvenile fibroadenoma exhibited lower levels of anaphase-promoting complex7 and Ki-67 expression than did the phyllodes tumor. the frequency of anaphase-promoting complex7-positive stromal cells correlated with Ki-67 expression in phyllodes tumor and in all of the examined breast tumors. the above results indicate that anaphase-promoting complex7 and Ki-67 are closely related to cell proliferation. in addition, phyllodes tumor can be differentiated from juvenile fibroadenoma with increased mitotic figures mimicking phyllodes tumor by anaphase-promoting complex7 and Ki-67 immunochemistry. Because anaphase-promoting complex7 is expressed at higher levels than is Ki-67, it may overcome the limitations of the Ki-67 labeling index with regard to the differentiation of benign phyllodes tumor from fibroadenoma.
Full Text
http://www.sciencedirect.com/science/article/pii/S0046817708002931
DOI
10.1016/j.humpath.2008.04.023
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tai Seung(김태승)
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Jung, Woo Hee(정우희)
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103470
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