Cited 12 times in
Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast
DC Field | Value | Language |
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dc.contributor.author | 박병우 | - |
dc.contributor.author | 정우희 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 김태승 | - |
dc.date.accessioned | 2015-04-24T16:24:54Z | - |
dc.date.available | 2015-04-24T16:24:54Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0046-8177 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103470 | - |
dc.description.abstract | The proteolytic destruction of cyclin B is an important event during cell division. Cyclin B proteolysis is triggered by the anaphase-promoting complex. Therefore, cell cycle dysregulation due to anaphase-promoting complex loss contributes to cell transformation and human carcinogenesis. This study investigates anaphase-promoting complex7 expression in spindle cell breast tumors and also includes a comparison between the proliferation antigen Ki-67 and S-phase fraction. the average values of the anaphase-promoting complex7 and Ki-67 labeling indices increased in order from benign to malignant within the phyllodes tumor group, and the fibroadenoma and juvenile fibroadenoma exhibited lower levels of anaphase-promoting complex7 and Ki-67 expression than did the phyllodes tumor. the frequency of anaphase-promoting complex7-positive stromal cells correlated with Ki-67 expression in phyllodes tumor and in all of the examined breast tumors. the above results indicate that anaphase-promoting complex7 and Ki-67 are closely related to cell proliferation. in addition, phyllodes tumor can be differentiated from juvenile fibroadenoma with increased mitotic figures mimicking phyllodes tumor by anaphase-promoting complex7 and Ki-67 immunochemistry. Because anaphase-promoting complex7 is expressed at higher levels than is Ki-67, it may overcome the limitations of the Ki-67 labeling index with regard to the differentiation of benign phyllodes tumor from fibroadenoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 98~107 | - |
dc.relation.isPartOf | HUMAN PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anaphase-Promoting Complex-Cyclosome | - |
dc.subject.MESH | Breast Neoplasms/genetics | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibroadenoma/genetics | - |
dc.subject.MESH | Fibroadenoma/metabolism* | - |
dc.subject.MESH | Fibroadenoma/pathology | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Ki-67 Antigen/metabolism | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Phyllodes Tumor/genetics | - |
dc.subject.MESH | Phyllodes Tumor/metabolism* | - |
dc.subject.MESH | Phyllodes Tumor/pathology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | S Phase | - |
dc.subject.MESH | Ubiquitin-Protein Ligase Complexes/genetics | - |
dc.subject.MESH | Ubiquitin-Protein Ligase Complexes/metabolism* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Yup Kang | - |
dc.contributor.googleauthor | Jang Hee Kim | - |
dc.contributor.googleauthor | Tae Hui Lee | - |
dc.contributor.googleauthor | Tai Seung Kim | - |
dc.contributor.googleauthor | Woo Hee Jung | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Byeong Woo Park | - |
dc.contributor.googleauthor | Seung Soo Sheen | - |
dc.contributor.googleauthor | Jae Ho Han | - |
dc.identifier.doi | 10.1016/j.humpath.2008.04.023 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01475 | - |
dc.contributor.localId | A03671 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A01071 | - |
dc.relation.journalcode | J01011 | - |
dc.identifier.eissn | 1532-8392 | - |
dc.identifier.pmid | 18789487 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0046817708002931 | - |
dc.subject.keyword | Anaphase-promoting complex | - |
dc.subject.keyword | Ki-67 | - |
dc.subject.keyword | Phyllodes tumor | - |
dc.subject.keyword | Fibroadenoma | - |
dc.contributor.alternativeName | Park, Byeong Woo | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Kim, Tai Seung | - |
dc.contributor.affiliatedAuthor | Park, Byeong Woo | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Kim, Tai Seung | - |
dc.citation.volume | 40 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 98 | - |
dc.citation.endPage | 107 | - |
dc.identifier.bibliographicCitation | HUMAN PATHOLOGY, Vol.40(1) : 98-107, 2009 | - |
dc.identifier.rimsid | 36023 | - |
dc.type.rims | ART | - |
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