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Targeting to carcinoma cells with chitosan- and starch-coated magnetic nanoparticles for magnetic hyperthermia

Authors
 Dong-Hyun Kim  ;  Kyoung-Nam Kim  ;  Kwang-Mahn Kim  ;  Yong-Keun Lee 
Citation
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol.88A(1) : 1-11, 2009 
Journal Title
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 
ISSN
 1549-3296 
Issue Date
2009
MeSH
Cell Line, Tumor ; Chitosan ; Coated Materials, Biocompatible/chemistry ; Coated Materials, Biocompatible/therapeutic use* ; Drug Delivery Systems/methods* ; Fever/chemically induced* ; Humans ; Magnetics* ; Materials Testing ; Nanoparticles/administration & dosage* ; Nanoparticles/chemistry ; Neoplasms/pathology ; Spectroscopy, Fourier Transform Infrared ; Starch ; X-Ray Diffraction
Keywords
magnetic ; targeting ; hyperthermia ; carcinoma cell
Abstract
The delivery of hyperthermic thermoseeds to a specific target site with minimal side effects is an important challenge in targeted hyperthermia, which employs magnetic method and functional polymers. An external magnetic field is used to control the site-specific targeting of the magnetic nanoparticles. Polymer-coated magnetic nanoparticles can confer a higher affinity to the biological cell membranes. In this study, uncoated, chitosan-coated, and starch-coated magnetic nanoparticles were synthesized for use as a hyperthermic thermoseed. Each sample was examined with respect to their applications to hyperthermia using XRD, VSM, and FTIR. In addition, the temperature changes under an alternating magnetic field were observed. As in vitro tests, the magnetic responsiveness of chitosan- and starch-coated magnetite was determined by a simple blood vessel model under various intensities of magnetic field. L929 normal cells and KB carcinoma cells were used to examine the cytotoxicity and affinity of each sample using the MTT method. The chitosan-coated magnetic nanoparticles generated a higher DeltaT of 23 degrees C under an AC magnetic field than the starch-coated magnetite, and the capturing rate of the particles was 96% under an external magnetic field of 0.4 T. The highest viability of L929 cells was 93.7%. Comparing the rate of KB cells capture with the rate of L929 cells capture, the rate of KB cells capture relatively increased with 10.8% in chitosan-coated magnetic nanoparticles. Hence, chitosan-coated magnetic nanoparticles are biocompatible and have a selective affinity to KB cells. The targeting of magnetic nanoparticles in hyperthermia was improved using a controlled magnetic field and a chitosan-coating. Therefore, chitosan-coated magnetic nanoparticles are expected to be promising materials for use in magnetic targeted hyperthermia.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.31775/abstract
DOI
10.1002/jbm.a.31775
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyoung Nam(김경남)
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
Kim, Dong Hyun(김동현)
Lee, Yong Keun(이용근)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103456
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