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Preoperative C-reactive protein levels are associated with tumor size and lymphovascular invasion in resected non-small cell lung cancer.

Authors
 Jin Gu Lee  ;  Byoung Chul Cho  ;  Mi Kyung Bae  ;  Chang Young Lee  ;  In Kyu Park  ;  Dae Joon Kim  ;  Song Vogue Ahn  ;  Kyung Young Chung 
Citation
 Lung Cancer, Vol.63(1) : 106-110, 2009 
Journal Title
 Lung Cancer 
ISSN
 0169-5002 
Issue Date
2009
MeSH
Adult ; Aged ; Biomarkers, Tumor ; C-Reactive Protein/biosynthesis* ; C-Reactive Protein/metabolism ; Carcinoma, Non-Small-Cell Lung/blood* ; Carcinoma, Non-Small-Cell Lung/metabolism ; Female ; Humans ; Lung Neoplasms/blood* ; Lung Neoplasms/metabolism ; Lymphatic Metastasis ; Male ; Middle Aged ; Models, Biological ; Neoplasm Invasiveness ; Neoplasms/metabolism* ; Regression Analysis
Keywords
Non-small cell lung cancer ; C-reactive protein ; Lymphovascular invasion ; Tumor size
Abstract
BACKGROUND: This study focused on the association between preoperative serum C-reactive protein (CRP) levels and pathologic parameters in patients with resected non-small cell lung cancer (NSCLC). Our primary objective was to find pathologic factors that may explain poor prognosis in patients with preoperative serum CRP elevation. METHODS: The records of 102 patients who had undergone pulmonary resection of NSCLC were reviewed. The association between preoperative serum CRP levels and variables that had p-values of less than 0.05 in t-test or one-way ANOVA was examined using multiple linear regression analysis. RESULTS: Mean serum CRP level prior to surgery was 3.8+/-4.9 (range, 0.1-19.8) mg/dL. The Pearson correlation coefficient indicated that serum CRP level and pathologic tumor diameter are positively correlated (r=0.487, p<0.001). Serum CRP levels were associated with sex (male vs. female, p=0.003), smoking status (smoker vs. never smoker, p=0.007), histology (squamous vs. non-squamous, p=0.001), tumor size (size>3 cm vs. size< or =3, p<0.001), tumor necrosis (yes vs. no, p<0.001), lymphovascular invasion (yes vs. no, p<0.001), and pleural invasion (P0 vs. P1 vs. P2 vs. P3, p=0.013), but not with age (age>64.5 vs. age< or =64.5, p=0.508), atelectasis or obstructive pneumonia (yes vs. no, p=0.119), location of tumor (peripheral vs. central, p=0.474), and lymph node involvement (N0 vs. N1 vs. N2 vs. N3, p=0.558). Multiple linear regression analysis indicated that pathologic tumor size (beta=0.583, p=0.005) and lymphovascular invasion (beta=3.002, p=0.009) were associated with preoperative serum CRP level. CONCLUSION: Our results indicate that lymphovascular invasion and pathologic tumor size are associated with preoperative serum CRP level, which may be considered a prognostic factor in patients with NSCLC. This additional information might serve as a basis to explain poor prognosis in patients with preoperative serum CRP elevation.
Full Text
http://www.sciencedirect.com/science/article/pii/S0169500208002298
DOI
10.1016/j.lungcan.2008.04.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Joon(김대준)
Park, In Kyu(박인규)
Bae, Mi Kyung(배미경)
Lee, Jin Gu(이진구)
Chung, Kyung Young(정경영)
Cho, Byoung Chul(조병철) ORCID logo https://orcid.org/0000-0002-5562-270X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103449
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