Cited 55 times in
Preoperative C-reactive protein levels are associated with tumor size and lymphovascular invasion in resected non-small cell lung cancer.
DC Field | Value | Language |
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dc.contributor.author | 배미경 | - |
dc.contributor.author | 이진구 | - |
dc.contributor.author | 정경영 | - |
dc.contributor.author | 조병철 | - |
dc.contributor.author | 김대준 | - |
dc.contributor.author | 박인규 | - |
dc.date.accessioned | 2015-04-24T16:24:13Z | - |
dc.date.available | 2015-04-24T16:24:13Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0169-5002 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103449 | - |
dc.description.abstract | BACKGROUND: This study focused on the association between preoperative serum C-reactive protein (CRP) levels and pathologic parameters in patients with resected non-small cell lung cancer (NSCLC). Our primary objective was to find pathologic factors that may explain poor prognosis in patients with preoperative serum CRP elevation. METHODS: The records of 102 patients who had undergone pulmonary resection of NSCLC were reviewed. The association between preoperative serum CRP levels and variables that had p-values of less than 0.05 in t-test or one-way ANOVA was examined using multiple linear regression analysis. RESULTS: Mean serum CRP level prior to surgery was 3.8+/-4.9 (range, 0.1-19.8) mg/dL. The Pearson correlation coefficient indicated that serum CRP level and pathologic tumor diameter are positively correlated (r=0.487, p<0.001). Serum CRP levels were associated with sex (male vs. female, p=0.003), smoking status (smoker vs. never smoker, p=0.007), histology (squamous vs. non-squamous, p=0.001), tumor size (size>3 cm vs. size< or =3, p<0.001), tumor necrosis (yes vs. no, p<0.001), lymphovascular invasion (yes vs. no, p<0.001), and pleural invasion (P0 vs. P1 vs. P2 vs. P3, p=0.013), but not with age (age>64.5 vs. age< or =64.5, p=0.508), atelectasis or obstructive pneumonia (yes vs. no, p=0.119), location of tumor (peripheral vs. central, p=0.474), and lymph node involvement (N0 vs. N1 vs. N2 vs. N3, p=0.558). Multiple linear regression analysis indicated that pathologic tumor size (beta=0.583, p=0.005) and lymphovascular invasion (beta=3.002, p=0.009) were associated with preoperative serum CRP level. CONCLUSION: Our results indicate that lymphovascular invasion and pathologic tumor size are associated with preoperative serum CRP level, which may be considered a prognostic factor in patients with NSCLC. This additional information might serve as a basis to explain poor prognosis in patients with preoperative serum CRP elevation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 106~110 | - |
dc.relation.isPartOf | LUNG CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers, Tumor | - |
dc.subject.MESH | C-Reactive Protein/biosynthesis* | - |
dc.subject.MESH | C-Reactive Protein/metabolism | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/blood* | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung Neoplasms/blood* | - |
dc.subject.MESH | Lung Neoplasms/metabolism | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Models, Biological | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Neoplasms/metabolism* | - |
dc.subject.MESH | Regression Analysis | - |
dc.title | Preoperative C-reactive protein levels are associated with tumor size and lymphovascular invasion in resected non-small cell lung cancer. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery (흉부외과학) | - |
dc.contributor.googleauthor | Jin Gu Lee | - |
dc.contributor.googleauthor | Byoung Chul Cho | - |
dc.contributor.googleauthor | Mi Kyung Bae | - |
dc.contributor.googleauthor | Chang Young Lee | - |
dc.contributor.googleauthor | In Kyu Park | - |
dc.contributor.googleauthor | Dae Joon Kim | - |
dc.contributor.googleauthor | Song Vogue Ahn | - |
dc.contributor.googleauthor | Kyung Young Chung | - |
dc.identifier.doi | 10.1016/j.lungcan.2008.04.011 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01792 | - |
dc.contributor.localId | A03225 | - |
dc.contributor.localId | A03571 | - |
dc.contributor.localId | A03822 | - |
dc.contributor.localId | A00368 | - |
dc.contributor.localId | A01625 | - |
dc.relation.journalcode | J02174 | - |
dc.identifier.eissn | 1872-8332 | - |
dc.identifier.pmid | 18513823 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0169500208002298 | - |
dc.subject.keyword | Non-small cell lung cancer | - |
dc.subject.keyword | C-reactive protein | - |
dc.subject.keyword | Lymphovascular invasion | - |
dc.subject.keyword | Tumor size | - |
dc.contributor.alternativeName | Bae, Mi Kyung | - |
dc.contributor.alternativeName | Lee, Jin Gu | - |
dc.contributor.alternativeName | Chung, Kyung Young | - |
dc.contributor.alternativeName | Cho, Byoung Chul | - |
dc.contributor.alternativeName | Kim, Dae Joon | - |
dc.contributor.alternativeName | Park, In Kyu | - |
dc.contributor.affiliatedAuthor | Bae, Mi Kyung | - |
dc.contributor.affiliatedAuthor | Lee, Jin Gu | - |
dc.contributor.affiliatedAuthor | Chung, Kyung Young | - |
dc.contributor.affiliatedAuthor | Cho, Byoung Chul | - |
dc.contributor.affiliatedAuthor | Kim, Dae Joon | - |
dc.contributor.affiliatedAuthor | Park, In Kyu | - |
dc.citation.volume | 63 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 106 | - |
dc.citation.endPage | 110 | - |
dc.identifier.bibliographicCitation | LUNG CANCER, Vol.63(1) : 106-110, 2009 | - |
dc.identifier.rimsid | 36010 | - |
dc.type.rims | ART | - |
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