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Acute promyelocytic leukemia in early pregnancy with translocation t(15;17) and variant PML/RARA fusion transcripts

Authors
 Tae Sung Park  ;  Seung Tae Lee  ;  Jin Seok Kim  ;  Jaewoo Song  ;  Kyung-A Lee  ;  Sue Jung Kim  ;  Yoon-Mi Seok  ;  Hyeon-Ji Lee  ;  Jeong-Hyun Han  ;  Jong-Kee Kim  ;  Eun Yup Lee  ;  Jong Rak Choi 
Citation
 CANCER GENETICS AND CYTOGENETICS , Vol.188(1) : 48-51, 2009 
Journal Title
 CANCER GENETICS AND CYTOGENETICS 
ISSN
 0165-4608 
Issue Date
2009
MeSH
Adult ; Antineoplastic Agents/therapeutic use ; Bone Marrow/pathology ; Female ; Humans ; Idarubicin/therapeutic use ; In Situ Hybridization, Fluorescence ; Karyotyping ; Korea ; Leukemia, Promyelocytic, Acute/diagnosis ; Leukemia, Promyelocytic, Acute/drug therapy ; Leukemia, Promyelocytic, Acute/genetics* ; Leukemia, Promyelocytic, Acute/pathology ; Nuclear Proteins/genetics* ; Oncogene Proteins, Fusion/genetics* ; Pregnancy ; Pregnancy Complications, Neoplastic/diagnosis ; Pregnancy Complications, Neoplastic/drug therapy ; Pregnancy Complications, Neoplastic/genetics* ; Pregnancy Complications, Neoplastic/pathology ; Promyelocytic Leukemia Protein ; Receptors, Retinoic Acid/genetics* ; Retinoic Acid Receptor alpha ; Reverse Transcriptase Polymerase Chain Reaction ; Transcription Factors/genetics* ; Translocation, Genetic* ; Tretinoin/therapeutic use ; Tumor Suppressor Proteins/genetics*
Abstract
A 32-year-old pregnant woman in the 13th gestational week was brought to Severance Hospital with gum bleeding and easy bruising. Initial laboratory results revealed anemia and thrombocytopenia. In a peripheral blood smear, 81% of leukocytes were large, abnormal promyelocytes. Bone marrow aspiration showed a hypercellular marrow with packed leukemic promyelocytes, and chromosome study revealed a karyotype of 46,XX,t(15;17)(q22;q21)[10]/46,XX[10]. In addition, variant fusion transcripts of PML/RARA were detected in the marrow specimen. The patient was diagnosed with acute promyelocytic leukemia (APL) and was treated with all-trans retinoic acid (ATRA) and idarubicin. One month from the patient's initial diagnosis a follow-up bone marrow examination was performed, revealing complete remission (CR). We know of no previous reports of APL during pregnancy associated with variant PML/RARA fusion transcripts. Here, we describe a novel case of APL in a pregnant woman with a t(15;17) translocation and variant fusion transcripts
Full Text
http://www.sciencedirect.com/science/article/pii/S0165460808004901
DOI
10.1016/j.cancergencyto.2008.08.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soo Jeong(김수정) ORCID logo https://orcid.org/0000-0001-8859-3573
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Park, Tae Sung(박태성)
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
Lee, Seung Tae(이승태)
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103410
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