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Prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer: impact of patterns of pelvic recurrence on curative resection

Authors
 Jea-Kun Park  ;  Young-Wan Kim  ;  Hyuk Hur  ;  Nam-Kyu Kim  ;  Byung-Soh Min  ;  Seung-Kook Sohn  ;  Young-Deuk Choi  ;  Young-Tae Kim  ;  Jung-Bai Ahn  ;  Jae-Kyung Roh  ;  Ki-Chang Keum  ;  Jin-Sil Seong 
Citation
 Langenbeck's Archives of Surgery, Vol.394(1) : 71-77, 2009 
Journal Title
 Langenbeck's Archives of Surgery 
ISSN
 1435-2443 
Issue Date
2009
Abstract
BACKGROUND: The purpose of this study is to investigate prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer and determine whether recurrence patterns influence curative resection of recurrent tumor. MATERIALS AND METHODS: We examined 62 patients with isolated local recurrence following total mesorectal excision (TME) of the primary rectal cancer. Recurrence patterns were classified as central, anterior, posterior, lateral, and perineal with respect to the intra-pelvic tumor location. Prognostic factors affecting oncologic outcomes were analyzed, and the rate of curative resection was analyzed according to recurrence patterns. RESULTS: The mean follow-up period was 49.0 +/- 29.0 months, and the mean time to recurrence after TME was 27.9 +/- 23.3 months. Twenty-three patients underwent curative resection, and the remaining 39 patients received palliative treatment. Patients with a central recurrence had the highest rate of curative resection (p = 0.006). The overall 5-year survival rate was 13.9% and significantly higher in those treated with curative resection (35.1%; p = 0.0002). Multivariate analysis demonstrated that disease-free survival less than 1 year and curative resection of local recurrence were independent prognostic factors influencing 5-year survival. CONCLUSION: Patients with central recurrences have a high probability of curative resection. Disease-free survival less than 1 year and curative resection of local recurrence were independent prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer
Full Text
http://link.springer.com/article/10.1007%2Fs00423-008-0391-6
DOI
10.1007/s00423-008-0391-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Young Wan(김영완)
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Roh, Jae Kyung(노재경)
Min, Byung Soh(민병소)
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Sohn, Seung Kook(손승국)
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Hur, Hyuk(허혁) ORCID logo https://orcid.org/0000-0002-9864-7229
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103383
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