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Pars plana vitrectomy with internal limiting membrane peeling compared with intravitreal triamcinolone injection in the treatment of diabetic macular edema

 Yong Min Kim  ;  Eun Jee Chung  ;  Suk Ho Byeon  ;  Sung Chul Lee  ;  Oh Woong Kwon  ;  Hyoung Jun Koh 
 OPHTHALMOLOGICA, Vol.223(1) : 17-23, 2009 
Journal Title
Issue Date
Aged ; Diabetic Retinopathy/complications* ; Epiretinal Membrane/surgery ; Female ; Glucocorticoids/administration & dosage* ; Glucocorticoids/adverse effects ; Humans ; Injections ; Intraocular Pressure/drug effects ; Macula Lutea/pathology ; Macular Edema/etiology* ; Macular Edema/pathology ; Macular Edema/physiopathology ; Macular Edema/surgery* ; Male ; Middle Aged ; Postoperative Period ; Retrospective Studies ; Time Factors ; Treatment Outcome ; Triamcinolone Acetonide/administration & dosage* ; Triamcinolone Acetonide/adverse effects ; Visual Acuity ; Vitrectomy* ; Vitreous Body
Diabetic macular edema ; Triamcinolone acetonide ; Vitrectomy
AIM: To compare the efficacy of pars plana vitrectomy (PPV) with internal limiting membrane (ILM) removal and intravitreal triamcinolone acetonide (IVTA) injection in patients with diabetic macular edema (DME). METHODS: This study was a retrospective, comparative, interventional case study examining 14 patients (15 eyes in total) who underwent PPV and ILM removal (vitrectomy group), and 14 patients (14 eyes in total) who were treated with an IVTA injection (triamcinolone group). Main outcome measures were visual acuity and central macular thickness at 1, 3 and 6 months postoperatively. RESULTS: Patients in the vitrectomy group had significantly decreased central macular thicknesses at 1, 3 and 6 months postoperatively (p = 0.001, p = 0.001 and p = 0.002, respectively). The improvement in visual acuity was not significant at 1 month, but it gradually became statistically significant at 3 and 6 months after surgery (p = 0.031 and p = 0.015, respectively). Compared with the triamcinolone group, the vitrectomy group showed a better visual acuity at 6 months after surgery (p = 0.025). CONCLUSIONS: PPV combined with ILM removal is a good therapeutic option for improving visual acuity and decreasing macular thickness in DME, and this treatment has a better long-term efficacy than a single IVTA injection.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
Kwon, Oh Woong(권오웅)
Byeon, Suk Ho(변석호) ORCID logo https://orcid.org/0000-0001-8101-0830
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Chung, Eun Jee(정은지)
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