유방병변의 초음파 유도하 총생검: 1년간의 의학적검사

Abstract

Purpose: The objective of our study was to determine the diagnostic accuracy, underestimation rate and false negative rate of sonographically guided core needle biopsy for breast lesions. Materials and Methods: In this retrospective study, we included a total of 1179 lesions from 1028 patients who had undergone sonographically guided 14-gauge core needle biopsies between March 2012 and February 2013. The sonographic category of breast lesions and the pathologic results of core needle biopsies were reviewed and correlated with that of surgery or vacuum assisted biopsy, or long term (> 1yr) imaging follow- up. Through this, the positive predictive value for each sonographic category, sensitivity, underestimation rate and false negative rate of core needle biopsy were evaluated. Results: A total of 1179 cases, the pathologic results for the core needle biopsy were benign in 647, high-risk in 157, ductal carcinoma in situ in 54, invasive cancer in 321. The positive predictive values for each sonographic category were as follows: 0.0% in category 2; 3.9% in category 3; 13.4% in category 4a; 63.1% in category 4b; 84.7% in category 4c and 99.0% in category 5. The sensitivity of core needle biopsy was 93.8% (375 of 400). The underestimation rate was 10.2% for high-risk lesion (47.4% of atypical ductal hyperplasia, 5.1% for non-atypical ductal hyperplasia) and 40.7% (22 of 54) for ductal carcinoma in situ. Of 647 benign lesions, 9 lesions were confirmed as malignancy, and the false negative rate was 1.4%. Conclusion: Sonographically guided core needle biopsy for 1 year in our hospital was accurate diagnostic tool for evaluating breast lesion.