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Osteonecrosis of the jaw induced by oral administration of bisphosphonates in Asian population: five cases

 W. Park  ;  N.-K. Kim  ;  M.-Y. Kim  ;  Y.-M. Rhee  ;  H. J. Kim 
 OSTEOPOROSIS INTERNATIONAL, Vol.21(3) : 527-533, 2010 
Journal Title
Issue Date
Administration, Oral ; Aged ; Aged, 80 and over ; Bone Density Conservation Agents/adverse effects* ; Diphosphonates/adverse effects* ; Female ; Humans ; Jaw Diseases/chemically induced* ; Jaw Diseases/diagnostic imaging ; Osteonecrosis/chemically induced* ; Osteonecrosis/diagnostic imaging ; Radiography, Panoramic ; Tomography, X-Ray Computed
Asian ; Jaw ; Oral administration of bisphosphonate ; Osteonecrosis ; Osteoporosis
SUMMARY: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) can occur irrespective of race. Old age and long-term use of corticosteroid may be a more reliable risk factor than racial characteristics. INTRODUCTION: BRONJ is an increasingly common problem. Most BRONJ occurs following an intravenous administration of bisphosphonate treatment for malignant bone disease and metastatic cancer. As the incidence of BRONJ caused by oral administration of bisphosphonate is quite low, it is believed that this medication is relatively safe and effective in preventing complications of osteoporosis, such as hip or spine fractures. The many known risk factors for BRONJ can be classified as drug-related, local, demographic, and systemic. One demographic and systemic risk factor is race. Most of the case reports of BRONJ present elderly, white women. METHODS: In this report, we describe five cases of BRONJ caused by oral administration of bisphosphonate in Asian population. RESULTS: All the patients were female and over 65 years old. Three patients had been prescribed with corticosteroids for rheumatoid arthritis. CONCLUSION: Irrespective of race, elderly women undergoing steroid therapy have an increased incidence of BRONJ even with oral administration of bisphosphonate.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Wonse(박원서) ORCID logo https://orcid.org/0000-0002-2081-1156
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
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