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Feasibility of sequential high-dose chemotherapy in advanced pediatric solid tumors

Authors
 Seung Yeon Kwon  ;  Sung Chul Won  ;  Jung Woo Han  ;  Yoon Jung Shin  ;  Chuhl Joo Lyu 
Citation
 PEDIATRIC HEMATOLOGY AND ONCOLOGY, Vol.27(1) : 1-12, 2010 
Journal Title
 PEDIATRIC HEMATOLOGY AND ONCOLOGY 
ISSN
 0888-0018 
Issue Date
2010
MeSH
Adolescent ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage* ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Child ; Child, Preschool ; Combined Modality Therapy ; Drug Administration Schedule ; Feasibility Studies ; Female ; Follow-Up Studies ; Humans ; Infant ; Male ; Neoplasms/drug therapy* ; Neoplasms/pathology ; Neoplasms/surgery ; Neuroblastoma/drug therapy ; Neuroblastoma/surgery ; Peripheral Blood Stem Cell Transplantation ; Remission Induction ; Retrospective Studies ; Rhabdomyosarcoma/drug therapy ; Rhabdomyosarcoma/surgery ; Salvage Therapy* ; Survival Analysis ; Transplantation Conditioning/adverse effects ; Transplantation, Autologous
Keywords
chemotherapy ; childhood solid tumors ; high-dose
Abstract
The purpose of this study was to evaluate the feasibility and tumor response of 3 cycles of sequential high-dose chemotherapy (HDCT) in advanced pediatric solid tumor patients. Medical records of 11 children who underwent 2 consequent courses of reduced conditioning HDCT followed by final HDCT with autologous HSC infusion were reviewed in a retrospective manner. Each median time to an absolute neutrophil count > 0.5 x 10(9)/L was 12, 13, and 12 days. Major toxic reactions were fever, infection, and vomiting. One patient experienced transplantation-related mortality. Nine patients showed complete and partial responses to the therapy at 6 months follow-up after final HDCT. Finally, 6 patients are alive without evidence of disease at median follow-up of 24 months. Even though it is a preliminary result, the authors think that this treatment could be a feasible treatment option for advanced pediatric solid tumor patients.
Full Text
http://informahealthcare.com/doi/abs/10.3109/14992020903352226
DOI
10.3109/14992020903352226
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Seung Yeon(권승연)
Won, Sung Chul(원성철)
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103058
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