Cited 4 times in
Feasibility of sequential high-dose chemotherapy in advanced pediatric solid tumors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권승연 | - |
dc.contributor.author | 원성철 | - |
dc.contributor.author | 유철주 | - |
dc.date.accessioned | 2015-04-23T17:45:00Z | - |
dc.date.available | 2015-04-23T17:45:00Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0888-0018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103058 | - |
dc.description.abstract | The purpose of this study was to evaluate the feasibility and tumor response of 3 cycles of sequential high-dose chemotherapy (HDCT) in advanced pediatric solid tumor patients. Medical records of 11 children who underwent 2 consequent courses of reduced conditioning HDCT followed by final HDCT with autologous HSC infusion were reviewed in a retrospective manner. Each median time to an absolute neutrophil count > 0.5 x 10(9)/L was 12, 13, and 12 days. Major toxic reactions were fever, infection, and vomiting. One patient experienced transplantation-related mortality. Nine patients showed complete and partial responses to the therapy at 6 months follow-up after final HDCT. Finally, 6 patients are alive without evidence of disease at median follow-up of 24 months. Even though it is a preliminary result, the authors think that this treatment could be a feasible treatment option for advanced pediatric solid tumor patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1~12 | - |
dc.relation.isPartOf | PEDIATRIC HEMATOLOGY AND ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Antineoplastic CombinedChemotherapyProtocols/administration & dosage* | - |
dc.subject.MESH | Antineoplastic CombinedChemotherapyProtocols/adverse effects | - |
dc.subject.MESH | Antineoplastic CombinedChemotherapyProtocols/therapeutic use | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | FeasibilityStudies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neoplasms/drug therapy* | - |
dc.subject.MESH | Neoplasms/pathology | - |
dc.subject.MESH | Neoplasms/surgery | - |
dc.subject.MESH | Neuroblastoma/drug therapy | - |
dc.subject.MESH | Neuroblastoma/surgery | - |
dc.subject.MESH | Peripheral Blood Stem Cell Transplantation | - |
dc.subject.MESH | Remission Induction | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Rhabdomyosarcoma/drug therapy | - |
dc.subject.MESH | Rhabdomyosarcoma/surgery | - |
dc.subject.MESH | Salvage Therapy* | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Transplantation Conditioning/adverse effects | - |
dc.subject.MESH | Transplantation, Autologous | - |
dc.title | Feasibility of sequential high-dose chemotherapy in advanced pediatric solid tumors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Seung Yeon Kwon | - |
dc.contributor.googleauthor | Sung Chul Won | - |
dc.contributor.googleauthor | Jung Woo Han | - |
dc.contributor.googleauthor | Yoon Jung Shin | - |
dc.contributor.googleauthor | Chuhl Joo Lyu | - |
dc.identifier.doi | 10.3109/14992020903352226 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00226 | - |
dc.contributor.localId | A02434 | - |
dc.contributor.localId | A02524 | - |
dc.relation.journalcode | J02890 | - |
dc.identifier.eissn | 1521-0669 | - |
dc.identifier.pmid | 20121550 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.3109/14992020903352226 | - |
dc.subject.keyword | chemotherapy | - |
dc.subject.keyword | childhood solid tumors | - |
dc.subject.keyword | high-dose | - |
dc.contributor.alternativeName | Kwon, Seung Yeon | - |
dc.contributor.alternativeName | Won, Sung Chul | - |
dc.contributor.alternativeName | Lyu, Chuhl Joo | - |
dc.contributor.affiliatedAuthor | Kwon, Seung Yeon | - |
dc.contributor.affiliatedAuthor | Won, Sung Chul | - |
dc.contributor.affiliatedAuthor | Lyu, Chuhl Joo | - |
dc.citation.volume | 27 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.identifier.bibliographicCitation | PEDIATRIC HEMATOLOGY AND ONCOLOGY, Vol.27(1) : 1-12, 2010 | - |
dc.identifier.rimsid | 35654 | - |
dc.type.rims | ART | - |
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