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Feasibility of sequential high-dose chemotherapy in advanced pediatric solid tumors

DC FieldValueLanguage
dc.contributor.author권승연-
dc.contributor.author원성철-
dc.contributor.author유철주-
dc.date.accessioned2015-04-23T17:45:00Z-
dc.date.available2015-04-23T17:45:00Z-
dc.date.issued2010-
dc.identifier.issn0888-0018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103058-
dc.description.abstractThe purpose of this study was to evaluate the feasibility and tumor response of 3 cycles of sequential high-dose chemotherapy (HDCT) in advanced pediatric solid tumor patients. Medical records of 11 children who underwent 2 consequent courses of reduced conditioning HDCT followed by final HDCT with autologous HSC infusion were reviewed in a retrospective manner. Each median time to an absolute neutrophil count > 0.5 x 10(9)/L was 12, 13, and 12 days. Major toxic reactions were fever, infection, and vomiting. One patient experienced transplantation-related mortality. Nine patients showed complete and partial responses to the therapy at 6 months follow-up after final HDCT. Finally, 6 patients are alive without evidence of disease at median follow-up of 24 months. Even though it is a preliminary result, the authors think that this treatment could be a feasible treatment option for advanced pediatric solid tumor patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1~12-
dc.relation.isPartOfPEDIATRIC HEMATOLOGY AND ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/administration & dosage*-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/adverse effects-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/therapeutic use-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHDrug Administration Schedule-
dc.subject.MESHFeasibility Studies-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHMale-
dc.subject.MESHNeoplasms/drug therapy*-
dc.subject.MESHNeoplasms/pathology-
dc.subject.MESHNeoplasms/surgery-
dc.subject.MESHNeuroblastoma/drug therapy-
dc.subject.MESHNeuroblastoma/surgery-
dc.subject.MESHPeripheral Blood Stem Cell Transplantation-
dc.subject.MESHRemission Induction-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRhabdomyosarcoma/drug therapy-
dc.subject.MESHRhabdomyosarcoma/surgery-
dc.subject.MESHSalvage Therapy*-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTransplantation Conditioning/adverse effects-
dc.subject.MESHTransplantation, Autologous-
dc.titleFeasibility of sequential high-dose chemotherapy in advanced pediatric solid tumors-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorSeung Yeon Kwon-
dc.contributor.googleauthorSung Chul Won-
dc.contributor.googleauthorJung Woo Han-
dc.contributor.googleauthorYoon Jung Shin-
dc.contributor.googleauthorChuhl Joo Lyu-
dc.identifier.doi10.3109/14992020903352226-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00226-
dc.contributor.localIdA02434-
dc.contributor.localIdA02524-
dc.relation.journalcodeJ02890-
dc.identifier.eissn1521-0669-
dc.identifier.pmid20121550-
dc.identifier.urlhttp://informahealthcare.com/doi/abs/10.3109/14992020903352226-
dc.subject.keywordchemotherapy-
dc.subject.keywordchildhood solid tumors-
dc.subject.keywordhigh-dose-
dc.contributor.alternativeNameKwon, Seung Yeon-
dc.contributor.alternativeNameWon, Sung Chul-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.affiliatedAuthorKwon, Seung Yeon-
dc.contributor.affiliatedAuthorWon, Sung Chul-
dc.contributor.affiliatedAuthorLyu, Chuhl Joo-
dc.citation.volume27-
dc.citation.number1-
dc.citation.startPage1-
dc.citation.endPage12-
dc.identifier.bibliographicCitationPEDIATRIC HEMATOLOGY AND ONCOLOGY, Vol.27(1) : 1-12, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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