Cited 18 times in
Is local radiotherapy still valuable for patients with multiple intrahepatic hepatocellular carcinomas?
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이두연 | - |
dc.contributor.author | 이종태 | - |
dc.contributor.author | 한광협 | - |
dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 성진실 | - |
dc.date.accessioned | 2015-04-23T17:39:52Z | - |
dc.date.available | 2015-04-23T17:39:52Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102893 | - |
dc.description.abstract | PURPOSE: To investigate whether local radiotherapy (RT) is valuable for patients with multiple hepatocellular carcinomas (HCCs). METHODS AND MATERIALS: From July 1992 to August 2006, 107 patients with unresectable HCC were treated with local RT after incomplete transcatheter arterial chemoembolization (TACE). The RT field included a main tumor with or without other tumor nodules, depending on the effectiveness of TACE. The median RT dose was 50.4 Gy in conventional fractionation. Patients were categorized into four groups: Group 1, single tumor (39 patients); Group 2, multiple tumors within the RT field (25 patients); Group 3, controlled tumors out of the RT field (19 patients); and Group 4, tumors that remained viable out of the RT field (24 patients). RESULTS: Group 1 showed the best survival rate (MST, 35 months; 2-year OS, 60%) and Group 4 the worst (MST, 5 months; 2-year OS, 16%). Group 2 and Group 3 showed similar survival (MST, 13 vs. 19 months; 2-year OS, 35% vs. 46%; p = 0.698). Significantly worse intrahepatic control in Group 4 was observed. The survival in Groups 2 and 3 (MST, 16 months) was significantly different from that in Group 4 (p = 0.004), and was marginally significant compared with that in Group 1 (p = 0.051). CONCLUSIONS: Local RT to the main tumor could be applicable in well-controlled intrahepatic tumors out of the RT field. Patients with viable intrahepatic tumors out of the RT field showed worse survival. In future clinical trials, these patients need to be excluded. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1433~1440 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Carcinoma, Hepatocellular/drug therapy | - |
dc.subject.MESH | Carcinoma, Hepatocellular/mortality* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology | - |
dc.subject.MESH | Carcinoma, Hepatocellular/radiotherapy* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/secondary | - |
dc.subject.MESH | Chemoembolization, Therapeutic/methods | - |
dc.subject.MESH | Combined Modality Therapy/methods | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infusions, Intra-Arterial/methods | - |
dc.subject.MESH | Liver Neoplasms/drug therapy | - |
dc.subject.MESH | Liver Neoplasms/mortality | - |
dc.subject.MESH | Liver Neoplasms/pathology | - |
dc.subject.MESH | Liver Neoplasms/radiotherapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasms, Multiple Primary/drug therapy | - |
dc.subject.MESH | Neoplasms, Multiple Primary/mortality* | - |
dc.subject.MESH | Neoplasms, Multiple Primary/pathology | - |
dc.subject.MESH | Neoplasms, Multiple Primary/radiotherapy* | - |
dc.subject.MESH | Radiotherapy Dosage | - |
dc.subject.MESH | Remission Induction | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Tumor Burden | - |
dc.title | Is local radiotherapy still valuable for patients with multiple intrahepatic hepatocellular carcinomas? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery (흉부외과학) | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Jinsil Seong | - |
dc.contributor.googleauthor | Kwang Hyub Han | - |
dc.contributor.googleauthor | Do Yun Lee | - |
dc.contributor.googleauthor | Jong Tae Lee | - |
dc.identifier.doi | 10.1016/j.ijrobp.2009.07.1676 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02745 | - |
dc.contributor.localId | A03150 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A01956 | - |
dc.relation.journalcode | J01157 | - |
dc.identifier.eissn | 1879-355X | - |
dc.identifier.pmid | 19896779 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0360301609027199 | - |
dc.contributor.alternativeName | Lee, Doo Yun | - |
dc.contributor.alternativeName | Lee, Jong Tae | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.affiliatedAuthor | Lee, Doo Yun | - |
dc.contributor.affiliatedAuthor | Lee, Jong Tae | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | Seong, Jin Sil | - |
dc.citation.volume | 77 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1433 | - |
dc.citation.endPage | 1440 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.77(5) : 1433-1440, 2010 | - |
dc.identifier.rimsid | 35073 | - |
dc.type.rims | ART | - |
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