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Clinicopathologic features of metachronous or synchronous gastric cancer patients with three or more primary sites

Authors
 Joo Hoon Kim  ;  Sun Young Rha  ;  Chan Kim  ;  Gun Min Kim  ;  Sang Hyun Yoon  ;  Ki Hyang Kim  ;  Min Jae Kim  ;  Joong Bae Ahn  ;  Hyun Cheol Chung  ;  Jae Kyung Roh  ;  Hyo Song Kim 
Citation
 Cancer Research and Treatment, Vol.42(4) : 217-224, 2010 
Journal Title
 Cancer Research and Treatment 
ISSN
 1598-2998 
Issue Date
2010
Abstract
PURPOSE: We investigated the clinicopathologic information of patients with gastric cancer with multiple primary cancers (GC-MPC) of three or more sites. MATERIALS AND METHODS: Between 1995 and 2009, 105,908 patients were diagnosed with malignancy at Severance Hospital, Yonsei University Health System. Of these, 113 (0.1%) patients with MPC of three or more sites were registered, and 41 (36.3%) of these were GC-MPC. We retrospectively reviewed the clinical data and overall survival using the medical records of these 41 GC-MPC patients. We defined synchronous cancers as those occurring within 6 months of the first primary cancer, while metachronous cancers were defined as those occurring more than 6 months later. RESULTS: Patients with metachronous GC-MPC were more likely to be female (p=0.003) and young than patients with synchronous GC-MPC (p=0.013). The most common cancer sites for metachronous GC-MPC patients were the colorectum, thyroid, lung, kidney and breast, while those for synchronous GC-MPC were the head and neck, esophagus, lung, and kidney. Metachronous GC-MPC demonstrated significantly better overall survival than synchronous GC-MPC, with median overall survival durations of 4.7 and 14.8 years, respectively, and 10-year overall survival rates of 48.2% and 80.7%, respectively (p<0.001). CONCLUSION: Multiplicity of primary malignancies itself does not seem to indicate a poor prognosis. The early detection of additional primary malignancies will enable proper management with curative intent
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DOI
10.4143/crt.2010.42.4.217
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김건민(Kim, Gun Min) ORCID logo https://orcid.org/0000-0001-9167-8682
김기향(Kim, Ki Hyang)
김민재(Kim, Min Jae)
김주훈(Kim, Joo Hoon)
김찬(Kim, Chan)
김효송(Kim, Hyo Song) ORCID logo https://orcid.org/0000-0002-0625-9828
노재경(Roh, Jae Kyung)
라선영(Rha, Sun Young) ORCID logo https://orcid.org/0000-0002-2512-4531
안중배(Ahn, Joong Bae) ORCID logo https://orcid.org/0000-0001-6787-1503
윤상현(Yoon, Sang Hyun)
정현철(Chung, Hyun Cheol) ORCID logo https://orcid.org/0000-0002-0920-9471
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102872
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