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Current advances in adenovirus nanocomplexes: more specificity and less immunogenicity

Authors
 Eunah Kang  ;  Chae-Ok Yun 
Citation
 BMB REPORTS, Vol.43(12) : 781-788, 2010 
Journal Title
 BMB REPORTS 
ISSN
 1976-6696 
Issue Date
2010
MeSH
Adenoviridae/chemistry ; Adenoviridae/genetics* ; Adenoviridae/immunology ; Drug Carriers/chemistry ; Genetic Therapy ; Genetic Vectors/administration & dosage ; Humans ; Nanostructures/administration & dosage ; Nanostructures/chemistry* ; Neoplasms/therapy* ; Polymers/chemistry
Keywords
Adenovirus ; Nanocomplex ; Nanomaterial ; Oncolytic adenovirus ; PEG ; pHPMA
Abstract
An often overlooked issue in the field of adenovirus (Ad)-mediated cancer gene therapy is its limited capacity for effective systemic delivery. Although primary tumors can be treated effectively with intralesional injection of conventional Ad vectors, systemic metastasis is difficult to cure. Systemic administration of conventional naked Ads leads to acute accumulation of Ad particles in the liver, induction of neutralizing antibody, short blood circulation half-life, non-specific biodistribution in undesired organs, and low selective accumulation in the target disease site. Versatile strategies involving the modification of viral surfaces with polymers and nanomaterials have been designed for the purpose of maximizing Ad anti-tumor activity and specificity by systemic administration. Integration of viral and non-viral nanomaterials will substantially advance both fields, creating new concepts in gene therapeutics. This review focuses on current advances in the development of smart Ad hybrid nanocomplexes based on various design-based strategies for optimal Ad systemic administration.
Files in This Item:
T201004897.pdf Download
DOI
10.5483/BMBRep.2010.43.12.781
Appears in Collections:
5. Research Institutes (연구소) > Institute for Cancer Research (암연구소) > 1. Journal Papers
Yonsei Authors
Yun, Chae Ok(윤채옥)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102780
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