Cited 77 times in
Autologous bone marrow infusion activates the progenitor cell compartment in patients with advanced liver cirrhosis.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경식 | - |
dc.contributor.author | 김도영 | - |
dc.contributor.author | 김명진 | - |
dc.contributor.author | 김수정 | - |
dc.contributor.author | 김자경 | - |
dc.contributor.author | 김진석 | - |
dc.contributor.author | 김현옥 | - |
dc.contributor.author | 박미숙 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 백용한 | - |
dc.contributor.author | 석재연 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 이관식 | - |
dc.contributor.author | 전재윤 | - |
dc.contributor.author | 정용은 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2015-04-23T17:35:33Z | - |
dc.date.available | 2015-04-23T17:35:33Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0963-6897 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102757 | - |
dc.description.abstract | Several clinical trials of bone marrow cell infusion in patients with liver cirrhosis (LC) have shown clinical improvement, despite conflicting results from animal models. We investigated serial pathological features and the clinical impact after autologous bone marrow infusion (ABMI) in patients with advanced LC. Ten patients with advanced LC due to chronic hepatitis B virus infection underwent ABMI. Serological tests, MRI, and liver biopsies were performed, and quality of life was assessed by a questionnaire. Median serum albumin and hemoglobin levels increased significantly after ABMI. All patients showed an improvement in quality of life, with no serious adverse events. Liver volume, measured by MRI, increased in 80% of the patients, and ascites decreased after ABMI. Child-Pugh scores were also significantly improved at 6 months after ABMI. In the serially biopsied livers, a gradually increasing activation of the hepatic progenitor cell (HPC) compartment, including HPC activation (ductular reaction) and HPC differentiation (intermediate hepatocyte), reached a peak after 3 months, with continued proliferation of hepatocytes, and returned to baseline levels after 6 months. There was no significant change in grade or stage of liver fibrosis or stellate cell activation after ABMI. ABMI is suggested to improve liver function and to activate the progenitor cell compartment. Although clinical improvement was sustained for more than 6 months, histological changes in the liver returned to baseline 6 months after ABMI. Further comparative studies are warranted. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1237~1246 | - |
dc.relation.isPartOf | CELL TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Bone Marrow Cells/cytology* | - |
dc.subject.MESH | Bone Marrow Transplantation* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hepatitis B, Chronic/complications | - |
dc.subject.MESH | Hepatitis B, Chronic/pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Cirrhosis/complications | - |
dc.subject.MESH | Liver Cirrhosis/pathology | - |
dc.subject.MESH | Liver Cirrhosis/surgery* | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Quality of Life | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Stem Cells/cytology | - |
dc.subject.MESH | Surveys and Questionnaires | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Transplantation, Autologous | - |
dc.title | Autologous bone marrow infusion activates the progenitor cell compartment in patients with advanced liver cirrhosis. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Kim, Ja Kyung | - |
dc.contributor.googleauthor | Park, Young Nyun | - |
dc.contributor.googleauthor | Kim, Jin Seok | - |
dc.contributor.googleauthor | Park, Mi-Suk | - |
dc.contributor.googleauthor | Paik, Yong Han | - |
dc.contributor.googleauthor | Seok, Jae-Yeon | - |
dc.contributor.googleauthor | Chung, Yong Eun | - |
dc.contributor.googleauthor | Kim, Hyun Ok | - |
dc.contributor.googleauthor | Kim, Kyung Sik | - |
dc.contributor.googleauthor | Ahn, Sang Hoon | - |
dc.contributor.googleauthor | Kim, Do Young | - |
dc.contributor.googleauthor | Kim, Myeong-Jin | - |
dc.contributor.googleauthor | Lee, Kwan Sik | - |
dc.contributor.googleauthor | Chon, Chae Yoon | - |
dc.contributor.googleauthor | Kim, Soo Jeong | - |
dc.contributor.googleauthor | Terai, Shuji | - |
dc.contributor.googleauthor | Sakaida, Isao | - |
dc.contributor.googleauthor | Han, Kwang-Hyub | - |
dc.identifier.doi | 10.3727/096368910X506863 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00299 | - |
dc.contributor.localId | A00426 | - |
dc.contributor.localId | A00633 | - |
dc.contributor.localId | A00852 | - |
dc.contributor.localId | A01017 | - |
dc.contributor.localId | A01122 | - |
dc.contributor.localId | A01463 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A01829 | - |
dc.contributor.localId | A01928 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A02666 | - |
dc.contributor.localId | A03662 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A03544 | - |
dc.contributor.localId | A00385 | - |
dc.relation.journalcode | J00492 | - |
dc.identifier.eissn | 1555-3892 | - |
dc.identifier.pmid | 20525430 | - |
dc.identifier.url | http://www.ingentaconnect.com/content/cog/ct/2010/00000019/00000010/art00003 | - |
dc.subject.keyword | Adult bone marrow stem cell | - |
dc.subject.keyword | Autologous bone marrow transplantation | - |
dc.subject.keyword | Liver cirrhosis | - |
dc.subject.keyword | Liver regeneration | - |
dc.subject.keyword | Progenitor cell | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Kim, Myeong Jin | - |
dc.contributor.alternativeName | Kim, Soo Jeong | - |
dc.contributor.alternativeName | Kim, Ja Kyung | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.alternativeName | Kim, Hyun Ok | - |
dc.contributor.alternativeName | Park, Mi Sook | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Paik, Yong Han | - |
dc.contributor.alternativeName | Seok, Jae Yeon | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Lee, Kwan Sik | - |
dc.contributor.alternativeName | Chon, Chae Yoon | - |
dc.contributor.alternativeName | Chung, Yong Eun | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Sik | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Jin | - |
dc.contributor.affiliatedAuthor | Kim, Soo Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Ja Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ok | - |
dc.contributor.affiliatedAuthor | Park, Mi-Suk | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Paik, Yong Han | - |
dc.contributor.affiliatedAuthor | Seok, Jae Yeon | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Kwan Sik | - |
dc.contributor.affiliatedAuthor | Chung, Yong Eun | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Chon, Chae Yoon | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.citation.volume | 19 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1237 | - |
dc.citation.endPage | 1246 | - |
dc.identifier.bibliographicCitation | CELL TRANSPLANTATION, Vol.19(10) : 1237-1246, 2010 | - |
dc.identifier.rimsid | 56940 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.