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Effects of LNG-IUS on nerve growth factor and its receptors expression in patients with adenomyosis.

Authors
 Young Sik Choi  ;  SiHyun Cho  ;  Kyung Jin Lim  ;  Young Eun JEON  ;  Hyo In Yang  ;  Kyung Eun Lee  ;  Kamdar Heena  ;  Seok Kyo Seo  ;  Hye Yeon Kim  ;  Byung Seok Lee Read More: http://informahealthcare.com/doi/abs/10.3109/08977194.2010.511619 
Citation
 GROWTH FACTORS, Vol.28(6) : 452-460, 2010 
Journal Title
 GROWTH FACTORS 
ISSN
 0897-7194 
Issue Date
2010
MeSH
Adult ; Dysmenorrhea/drug therapy ; Endometriosis/drug therapy ; Endometriosis/metabolism* ; Female ; Fluorescent Antibody Technique ; Humans ; Levonorgestrel/administration & dosage* ; Levonorgestrel/therapeutic use ; Middle Aged ; Nerve Growth Factor/genetics ; Nerve Growth Factor/metabolism* ; Receptors, Nerve Growth Factor/genetics ; Receptors, Nerve Growth Factor/metabolism*
Keywords
Nerve growth factor ; NGF receptor p75 ; NGF-specific tyrosine kinase receptor-A (TrkA) ; immunohistochemistry ; adenomyosis
Abstract
The levonorgestrel-releasing intrauterine system (LNG-IUS) is effective in the treatment of dysmenorrhea associated with adenomyosis. However, the mechanism of pain relief of LNG-IUS in patients with adenomyosis is unclear. We aimed to investigate the effects of LNG-IUS on the expression of nerve growth factor (NGF) and its receptors, NGFR p75 and TrkA in patients with adenomyosis. Endometrial and myometrial tissues were prepared from 17 LNG-IUS-treated patients and 15 hormonally untreated patients who had undergone hysterectomies for adenomyosis. Immunohistochemistry with antibodies against NGF, NGFR p75, and TrkA, was performed. The expression of NGF, NGFR p75, and TrkA in endometrium and myometrium of LNG-IUS-treated patients was significantly decreased compared to those of hormonally untreated patients. Our findings may indicate that the suppression of NGF and its receptors by LNG-IUS is another possible mechanism of relieving pain in patients with adenomyosis.
Full Text
http://informahealthcare.com/doi/abs/10.3109/08977194.2010.511619
DOI
10.3109/08977194.2010.511619
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hye Yeon(김혜연)
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Yang, Hyo In(양효인)
Lee, Kyung Eun(이경은)
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Lim, Kyung Jin(임경진)
Jeon, Young Eun(전영은)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102749
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